Fulminant neonatal sepsis due to Streptococcus alactolyticus -A case report and review

Toepfner, Nicole; Shetty, Sindhu; Kunze, Mirjam; Orlowska-Volk, Marzenna; Krüger, Markus; Berner, Reinhard; Hentschel, Roland

doi:10.1111/apm.12219

Cited by 17 publications

(13 citation statements)

References 8 publications

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“…S. alactolyticus was reported as a causative agent in a patient with IE complicated by septic emboli (14). Another fatal case of fulminant neonatal sepsis caused by this pathogen was also reported (15). Our patient presented with S. alactolyticus bacteriemia and aortic valve endocarditis.…”

Section: Discussionmentioning

confidence: 52%

A rare case of bacterial infective endocarditis caused by Streptococcus alactolyticus

Çekmen¹,

Baysan²,

Disbudak³

et al. 2019

HVT

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Background: Streptococcus alactolyticus is a rarely isolated bacterium, which classified under DNA cluster IV of the S. Bovis/S. equinus complex. Infections, especially infective endocarditis, caused by Strep. alactolyticus are very rare in humans. Case Report: We describe a case of Strepotoccocus alactolyticus bacteriemia complicated by infective endocarditis. A 64-year-old male with a previous history of coronary artery bypass grafting applied to our cardiology outpatient clinic with complaints of dyspnea, fever, confusion and an apical holosystolic murmur. He was admitted to the intensive care unit. Transthoracic and transesophageal echocardiography showed the presence vegetation on the aortic valve. S. alactolyticus was detected on serial blood cultures. The patient was first treated with intensive antimicrobial therapy, and then underwent mitral and aortic valve replacements with uneventful follow-up. Conclusion: Streptococcus alactolyticus infective endocarditis has only been reported previously in one patient. More information is certainly needed for diagnosis and treatment of patients infected with Streptococcus alactolyticus. Key words: Streptococcus alactolyticus, endocarditis

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Section: Discussionmentioning

confidence: 52%

A rare case of bacterial infective endocarditis caused by Streptococcus alactolyticus

Çekmen¹,

Baysan²,

Disbudak³

et al. 2019

HVT

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“…Gram's stain of the abscess wall confirmed the presence of Gram-positive cocci strengthening the hypothesis that this novel bacterium was the possible cause of the abscess. S alactolyticus has been isolated from birds, pigs and human beings (Vandamme and others 1999, Toepfner and others 2014), but it is likely that this is the first time it has been reported as associated with infection in sheep (Encyclopedia 2016). …”

Section: Discussionmentioning

confidence: 99%

Acquired megaoesophagus in a Suffolk ram

Laurence

Curnow

Blignaut

2016

Vet Record Case Reports

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A one-year-old Suffolk ram was evaluated after a four-month history of intermittent left-sided bloating and regurgitation. The ram had been slowly losing condition while other sheep in the cohort were gaining weight. Severe megaoesophagus was confirmed on lateral thoracic and neck radiographs and a firm, 6-cm mass at the oesophageal sphincter was palpated during standing exploratory laparotomy. Postmortem examination confirmed an abscess was the cause of the partial oesophageal obstruction. The abscess yielded pure light growth of Streptococcus alactolyticus, an organism not reported to be associated with infection in sheep. Intermittent bloating is an unusual presentation in ruminants, and acquired megaoesophagus has been reported only very occasionally in sheep. This case report expands the list of differential diagnoses for abnormal regurgitation and intermittent bloating, and provides another specific cause of obstructive gastrointestinal disease in sheep. Acquired megaoesophagus was an unusual sequela of this primary disease.

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“…Despite appropriate treatment, the patient showed no in clinical symptoms and signs and died within 23 hours of life. S. alactolyticus was identified in the gastric and tracheal fluid of the patient but no pathogen was found in the blood and CSF [2].…”

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confidence: 92%

“…S. alactolyticus is an extremely rare causative pathogen of human infection [1]. Until now, only three cases of human infection are reported, and only one of them was neonatal sepsis [2]. A 65-year-old woman with a history of left ventricular outflow tract obstruction in hypertrophic cardiomyopathy was diagnosed as S. alactolyticus infective endocarditis which was complicated by septic emboli and mycotic left middle cerebral artery aneurysm [4].…”

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confidence: 99%

“…A 35-year-old type 1 diabetic woman who presented with severe diabetic ketoacidosis, precipitated by S. alactolyticus bacteremia, was successfully treated [5]. Toepfner et al [2] described neonatal fulminant sepsis caused by S. alactolyticus; a fullterm infant that did not have any prenatal problem showed respiratory failure immediately after birth. Endotracheal intubation and mechanical ventilation were started, but the patient showed tachycardia, hypotension, and pulmonary hemorrhage.…”

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The First Case Report of Neonatal Bacterial Meningitis Caused by Streptococcus alactolyticus

et al. 2020

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Streptococcus alactolyticus is grouped in S. bovis/S. equinus complex (SBSEC). SBSEC is found in the intestinal flora of humans and animals [1]. Certain bacteria include in SBSEC have caused human infection such as bacteremia or meningitis, but S. alactolyticus was identified rarely as pathogen in a few case. Especially, only one case was reported in neonatal sepsis. A case of fatal neonatal sepsis without meningitis due to S. alactolyticus has been reported, but the pathogen was identified in gastric fluid and samples from ear, trachea, and nasopharynx, not in blood and cerebrospinal fluid (CSF) [2]. Until now, there was no case report that was culture-proven S. alactolyticus as pathogen of neonatal bacterial meningitis. This is the first case presenting neonatal bacterial meningitis and sepsis caused by S. alactolyticus and treated successfully. A 28-day-old baby girl presented to our hospital with 2 day-fever history. She was born at 36 weeks and 2 days of gestational age, weighing 2,800 g by cesarean section. There were no prenatal and perinatal problems. After birth, she was healthy, fed well and had been cared-for at home. She got hepatitis B vaccination at birth. Examinations on other hospital revealed a fever, heart rate, and respiration rate of 38.7°C, 168 beats/min, and 44/min, respectively. There were Letter to the editor

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Fulminant neonatal sepsis due to Streptococcus alactolyticus -A case report and review

Cited by 17 publications

References 8 publications

A rare case of bacterial infective endocarditis caused by Streptococcus alactolyticus

A rare case of bacterial infective endocarditis caused by Streptococcus alactolyticus

Acquired megaoesophagus in a Suffolk ram

The First Case Report of Neonatal Bacterial Meningitis Caused by Streptococcus alactolyticus

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