Fulminant subacute sclerosing panencephalitis in an immunized 20-month-old Indian boy

Khursheed, Ahmad; Hota, Dayanand; Bhalla, K. K.; Kaushik, Jaya Shankar

doi:10.17712/nsj.2018.4.20180168

Cited by 3 publications

(3 citation statements)

References 5 publications

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“…To the Editor I have read the interesting case report by Khursheed et al, 1 published in October 2018's issue of Neurosciences (Riyadh). The authors nicely described a case of fulminant subacute sclerosing panencephalitis (SSPE) in a 20-month-old Indian patient who was fully vaccinated for measles.…”

Section: Fulminant Subacute Sclerosing Panencephalitis In An Immunizementioning

confidence: 99%

“…The authors nicely described a case of fulminant subacute sclerosing panencephalitis (SSPE) in a 20-month-old Indian patient who was fully vaccinated for measles. 1 I have 2 comments on it.…”

Section: Fulminant Subacute Sclerosing Panencephalitis In An Immunizementioning

confidence: 99%

“…Reply from the Author I thank Prof. Al-Mendalawi for his invaluable comments on our article published in October's issue of Neurosciences (Riyadh). 1 The 2 concerns raised by the author are valid and could have been incorporated in the discussion section of the report. In a study on characterization of measles virus strains in patients with SSPE, it was observed that none of the vaccine strain sequences were detected among those who were vaccinated.…”

Section: Mahmood D Al-mendalawi Department Of Paediatrics Al-kindy Cmentioning

confidence: 99%

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Fulminant subacute sclerosing panencephalitis in an immunized 20-month-old Indian boy

Al-Mendalaw¹,

Kaushik²

2019

Neurosciences

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Section: Fulminant Subacute Sclerosing Panencephalitis In An Immunizementioning

confidence: 99%

Section: Fulminant Subacute Sclerosing Panencephalitis In An Immunizementioning

confidence: 99%

Section: Mahmood D Al-mendalawi Department Of Paediatrics Al-kindy Cmentioning

confidence: 99%

See 1 more Smart Citation

Fulminant subacute sclerosing panencephalitis in an immunized 20-month-old Indian boy

Al-Mendalaw¹,

Kaushik²

2019

Neurosciences

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Contemporary Treatment Practices for Subacute Sclerosing Panencephalitis: A Nationwide Survey Among Adult and Pediatric Neurologists in India

Garg,

Makharia,

Agarwal

et al. 2024

Annals of Indian Academy of Neurology

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Background and Objectives: Subacute sclerosing panencephalitis (SSPE) is a progressive disorder caused due to the persistence of mutant measles virus in the brain. Treatment strategies for SSPE remain largely undefined, and there exists no information on how neurologists are currently managing SSPE. Methods: A survey-based study was conducted among Indian neurologists managing pediatric and adult patients with SSPE. A questionnaire-based survey was circulated by email regarding respondent demographics, preference for disease-modifying strategies, and symptomatic therapy. Results: Survey response was obtained from 298 neurologists (responder rate 9.5%) and eventually analyzed from 266 respondents who managed SSPE in routine practice. This included 222 (83.5%) adult and 44 (16.5%) pediatric neurologists from 21 states of India. Ninety-five respondents (35.7%) indicated that they always advised Isoprinosine (inosine pranobex) to their patients. Regarding interferon therapy, 121 (45.5%) reported never advising it, whereas 56 (21.1%) always advised it. For myoclonus, the most frequently used first-line drug was valproate (181, 68%), followed by levetiracetam (58, 21.8%). Most (150, 56.4%) of the respondents favored personalized therapy for the individual patient in terms of the duration of disease-modifying treatment. The patient follow-up was reported to be poor, with most (171, 64.3%) of the patients following up only occasionally and 24 (9%) respondents indicating that patients are lost to follow-up promptly after the initial visit. Conclusions: While SSPE remains a vaccine-preventable illness and the focus should be on prevention through vaccination, there is an unmet urgent need among Indian neurologists for better-defined treatment strategies for patients with SSPE.

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SSPE in Children Younger than 3 Years

Kumar,

Pandey,

Uniyal

et al. 2022

Journal of Pediatric Neurosciences

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Subacute sclerosing panencephalitis (SSPE) is typically observed in school-going children, adolescents, and young adults. Herein, we report a 3-year-old boy of SSPE and systematically review all such reported cases (age ≤3 years). We searched PubMed database on June 16, 2020 with “English language & Human only” restrictions. Eligible publications were screened and retrieved by three authors (NK, SP, and RU). Variables like author, year of publication, country, age of onset, sex, duration of illness, immunization, history of measles, clinical presentation, neuroimaging, treatment, and outcome were extracted. Neurological outcome was assessed in terms of improvement, static course or death. The defined search criteria resulted in 791 manuscripts (1951 to June 16, 2020). Only 47 manuscripts were eligible for data extraction. Seventy cases were retrieved. The mean age of onset was 26.34 months. The M:F ratio was 3.2:1. Turkey (19 cases), India (10 cases), and Japan (10 cases) collectively comprised more than half cases of SSPE. Only six children were immunized, 17 have no measles immunization, and the rest 47 had insufficient immunization records. Preceding history of measles was present in 27 cases. Most patients presented in stage II/III with altered sensorium, myoclonic jerks, and seizures. The most common reported outcome was death (18/70) followed by vegetative state (10/70). The absence of measles vaccination is frequently associated with childhood SSPE. Early measles vaccination may prevent SSPE in toddlers. Perinatal measles infection results in short onset latency and fulminant course. Outcome was not good in reviewed age group of ≤3 years.

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Fulminant subacute sclerosing panencephalitis in an immunized 20-month-old Indian boy

Abstract: Figure 1 -Electroencephalograph (EEG) shows slowing (1-2 Hz, 20-30 uV) of sleep background with paucity of sleep markers. There are interspersed high amplitude (300-350 uV, 1-1.5 Hz) slow waves (A) that have a pseudoperiodic pattern (B) evident on decreasing the paper speed (B).

Cited by 3 publications

References 5 publications

Fulminant subacute sclerosing panencephalitis in an immunized 20-month-old Indian boy

Fulminant subacute sclerosing panencephalitis in an immunized 20-month-old Indian boy

Contemporary Treatment Practices for Subacute Sclerosing Panencephalitis: A Nationwide Survey Among Adult and Pediatric Neurologists in India

SSPE in Children Younger than 3 Years

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