Fulminant type 1 diabetes in Korea: high prevalence among patients with adult-onset type 1 diabetes

Cho, Y. M.; Kim, J. T.; Ko, Kyung Soo; Koo, Bo Kyeong; Yang, Sei Won; Park, M. H.; Lee, H. K.; Park, K. S.

doi:10.1007/s00125-007-0812-z

Cited by 76 publications

(62 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…However, the average HbA 1c level was 12.2% at onset; this accords with the new criteria in classical type 1A diabetes in our previous report, suggesting chronic hyperglycaemia due to continuous beta cell loss [3]. Fulminant type 1 diabetes is not uncommon in the Asian population, in which it accounts for approximately 20% of ketosis-onset type 1 diabetes [3,6]; it has also been reported in a white population [7]. In addition, it is noteworthy that almost all patients with fulminant type 1 diabetes are not children or adolescents, but adults [5].…”

supporting

confidence: 88%

Fulminant type 1 diabetes as an important exception to the new diagnostic criteria using HbA1c—response to the International Expert Committee

Imagawa

Hanafusa

2009

Diabetologia

View full text Add to dashboard Cite

supporting

confidence: 88%

Fulminant type 1 diabetes as an important exception to the new diagnostic criteria using HbA1c—response to the International Expert Committee

Imagawa

Hanafusa

2009

Diabetologia

View full text Add to dashboard Cite

“…after washing in distilled water once for 5 min, the slides only for natural killer (Nk) cells were exposed to microwave pretreatment in a target retrieval solution (Dako japan, kyoto, japan) at 100 °c for 15 min to enhance antigenisity. endogenous ria [5]. Several cases have been reported, not only in other asian populations, but also in caucasian populations [6,7].…”

Section: Immunohistochemistry and Morphometrymentioning

confidence: 99%

“…Saeko SHIBaSakI 1) , akIHISa IMaGaWa 1), 2) , SISko TaURIaINeN 3) , MoRIo IINo 4) , MaaRIT oIkaRINeN 3) , HIToSHI aBIRU 4) , keIjI TaMakI 4) , HIRoakI SeINo 5) , kaTSUHIRo NISHI 6) , IzUMI TakaSe 6) , YoSHIkaTSU okaDa 7) , Sae UNo 2) , YUko MURaSe-MISHIBa 1) , jUNGo TeRaSakI 1) , HIDeIcHI MakINo 8) , IIcHIRo SHIMoMURa 2) , HeIkkI HYöTY 3), 9) aND ToSHIakI HaNaFUSa 1) ably acute onset and absence of islet-related autoantibodies [2][3][4]. Fulminant type 1 diabetes has also shown high plasma glucose levels accompanied by ketosis or ketoacidosis.…”

Section: Expression Of Toll-like Receptors In the Pancreas Of Recent-mentioning

confidence: 99%

Expression of Toll-like Receptors in the Pancreas of Recent-onset Fulminant Type 1 Diabetes

et al. 2010

View full text Add to dashboard Cite

abstract. Fulminant type 1 diabetes, established in 2000, is defined as a novel subtype of diabetes mellitus that results from remarkably acute and almost complete destruction of pancreatic beta cells at the disease onset. In this study, we aimed to clarify the pathogenesis of fulminant type 1 diabetes with special reference to insulitis and viral infection. We examined pancreatic autopsy samples from three patients who had died soon after the onset of disease and analyzed these by immunohistochemistry and in situ hybridization. The results were that both beta and alpha cell areas were significantly decreased in comparison with those of normal controls. Mean beta cell area of the patients just after the onset was only 0.00256 % while that of normal control was 1.745 %. Macrophages and T cells-but no natural killer cells-had infiltrated the islets and the exocrine pancreas. Although both of them had massively infiltrated, macrophages dominated islet infiltration and were detected in 92.6 % of the patients' islets. Toll-like receptor (TLR) 3, a sensor of viral components, was detected in 84.7±7.0 % of macrophages and 62.7±32.3 % of T cells (mean±SD) in all three patients. TLR7 and TLR9 were also detected in the pancreas of all three patients. enterovirus RNa was detected in beta-cell positive islets in one of the three patients by in situ hybridization. In conclusion, our results suggest that macrophage-dominated insulitis rather than T cell autoimmunity contributes to beta cell destruction in fulminant type 1 diabetes.

show abstract

“…In Korea, the prevalence of FTD is 7.1% among all patients newly diagnosed with type 1 diabetes and 30.4% among patients with adult-onset diabetes (5). Interestingly, FTD is frequently observed in far eastern Asia; however, Caucasian FTD is very rare (4).…”

Section: Discussionmentioning

confidence: 99%

The First Vietnamese Patient with Fulminant Type 1 Diabetes Mellitus

Kim

Hahm

et al. 2012

Intern. Med.

View full text Add to dashboard Cite

A 23-year-old pregnant woman had a stillbirth at 30 weeks gestation due to abrupt diabetic ketoacidosis. The patient had a normal HbA1c, severe hyperglycemia, negative islet cell autoantibodies, and very low insulin secretion capacity. The viral markers associated with fulminant type 1 diabetes were negative. The patient's human leukocyte antigen genotypes were DRB1*04:06 and DQB1*03:01/05:02, not common subtypes for fulminant type 1 diabetes. This is the first Vietnamese patient with fulminant type 1 diabetes mellitus.

show abstract

Fulminant type 1 diabetes in Korea: high prevalence among patients with adult-onset type 1 diabetes

Abstract: Aims/hypothesis The aim of this study was to investigate

Cited by 76 publications

References 10 publications

Fulminant type 1 diabetes as an important exception to the new diagnostic criteria using HbA1c—response to the International Expert Committee

Fulminant type 1 diabetes as an important exception to the new diagnostic criteria using HbA1c—response to the International Expert Committee

Expression of Toll-like Receptors in the Pancreas of Recent-onset Fulminant Type 1 Diabetes

The First Vietnamese Patient with Fulminant Type 1 Diabetes Mellitus

Contact Info

Product

Resources

About