Fulminating Hyperpyrexia During Anaesthesia in a Member of a Myopathic Family

Abstract

We would like to thank Mr. W. D. Park, consultant surgeon, and Mr. Bernard Fairburn, consultant neurosurgeon, for permission to publish details of cases under their care. We are indebted to Mr. Sheppard for the photographs, and to the neurological department of the London Hospital for their assistance in the diagnosis of Barnes's myopathy.

Hypertrophy of the branchial muscles. A case with unusual features.

“…Some reports comment upon muscle hypertrophy in susceptible subjects (Steers et al, 1970;King et al, 1972;Harriman et al, 1973). The pathological changes observed in muscle biopsies are variable and non-specific (Harriman et al, 1973;Isaacs et al, 1973;Ellis et al, 1975).…”

Malignant hyperthermia: an investigation of five patients

“…TM In addition, there are statistical 1~176176 and genetic analyses. 44,46,61,81,1~176 There are a number of descriptions of malignant h v]3er-thermia in pigs ~~ in which the manifestations are similar to those in man. Several biochemical and microscopic 12~ studies exploring the cause of porcine malignant hyperthermia have been published, but their results and conclusions are not uniform.…”

“…10,17,26,74,81,99,101,108,109,141,143,145,146,150,158,187,188,189 This is not to say that the defects must be confined to skeletal muscle, nor does this necessarily mean that a defect in muscle is the primary lesion. 99,14~…”

Malignant hyperpyrexia: Further muscle studies in asymptomatic carriers identified by creatinine phosphokinase screening

“…In addition to their confirmation of the value of CPK in carrier detection, they found clinical evidence of myopathy. Steers et al (1970) found evidence of a myopathy in their susceptible family similar to that described by Barnes (1932). King, Denborough, and Zapf (1972) have suggested that susceptible individuals may show one of a number of specific myopathies consisting of a group with a dominantly inherited myopathy, a group who have myotonia congenita, and a third group with physical abnormalities and a progressive congenital myopathy.…”