Fumonisin B1 Contamination of Cereals and Risk of Esophageal Cancer in a High Risk Area in Northeastern Iran

Alizadeh, Ali Mohammad; Roshandel, Gholamreza; Roudbarmohammadi, Shahla; Roudbary, Maryam; Sohanaki, Hamid; Ghiasian, Seyed Amir; Taherkhani, Amir; Semnani, Shahryar; Aghasi, Maryam

doi:10.7314/apjcp.2012.13.6.2625

Cited by 114 publications

(75 citation statements)

References 28 publications

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“…A recent etiological study also found some positive correlation between prevalence of FB1 contamination in rice and incidence of esophageal cancer, though this relationship was not seen with other contaminated staple foods, such as corn, in the same region of Iran (Alizadeh et al 2012). …”

Section: Fumonisinsmentioning

confidence: 92%

Dietary mycotoxins, co-exposure, and carcinogenesis in humans: Short review

Ruyck

Boevre

Huybrechts

et al. 2015

Mutation Research/Reviews in Mutation Research

230

148

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Mycotoxins, toxic secondary metabolites of fungi, affect global agriculture so prolifically that they are virtually ubiquitous at some concentration in the average human diet. Studies of in vitro and in vivo toxicity are discussed, leading to investigations of co-exposed mycotoxins, as well as carcinogenic effects. Some of the most common and toxicologically significant mycotoxins, such as the aflatoxins, ochratoxins, fumonisins, deoxynivalenol, T-2 toxin, HT-2 toxin, patulin, zearalenone, and some ergot alkaloids are outlined. The wide variety of pathogenic mechanisms these compounds employ are shown capable of inducing a complex set of interactions. Of particular note are potential synergisms between mycotoxins with regard to carcinogenic attributable risk, indicating an important field for future study.

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Section: Fumonisinsmentioning

confidence: 92%

Dietary mycotoxins, co-exposure, and carcinogenesis in humans: Short review

Ruyck

Boevre

Huybrechts

et al. 2015

Mutation Research/Reviews in Mutation Research

230

148

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“…The proportion of FB1 contaminated rice samples was higher in high EC risk area than low risk area ( p = 0.02). 40 Researchers also found a positive relationship between aflatoxin level of wheat flour samples and the risk of EC in Golestan. 41 Although an earlier study did not suggest a major role for mycotoxins in EC.…”

Section: Introductionmentioning

confidence: 98%

Esophageal Cancer in Golestan Province, Iran: A Review of Genetic Susceptibility and Environmental Risk Factors

Gholipour¹,

Islami²,

Roshandel³

et al. 2016

Middle East J Dig Dis

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Esophageal squamous cell carcinoma (ESCC) is an aggressive tumor that is typically diagnosed only when the tumor has gained remarkable size, extended to peripheral tissues, and led to dysphagia. Five-year survival of advanced cancer is still very poor (19%), even with improved surgical techniques and adjuvant chemoradiation therapy. Therefore, early detection and prevention are the most important strategies to reduce the burden of ESCC. Our review will focus on the studies conducted in Golestan province, an area with a high prevalence of ESCC in northern Iran. We review three aspects of the research literature on ESCC: epidemiological features, environmental factors (including substance abuse, environmental contaminants, dietary factors, and human papillomavirus [HPV]), and molecular factors (including oncogenes, tumor suppressor genes, cell cycle regulatory proteins, and other relevant biomarkers). Epidemiological and experimental data suggest that some chemicals and lifestyle factors, including polycyclic aromatic hydrocarbons (PAHs), cigarette smoking, opium use, and hot tea drinking are associated with the development of ESCC in Golestan. HPV infects the esophageal epithelium, but so far, no firm evidence of its involvement in esophageal carcinogenesis has been provided. Some of these factors, notably hot tea drinking, may render the esophageal mucosa more susceptible to injury by other carcinogens. There are few studies at molecular level on ESCC in Golestan. Increasing awareness about the known risk factors of ESCC could potentially reduce the burden of ESCC in the region. Further studies on risk factors, identifying high risk populations, and early detection are needed.

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“…Few studies have examined the contamination of fumonisin in cereals. Alizadeh et al 2012, reported that Fumonisin B1 (FB1 a toxic and carcinogenic mycotoxin produced in cereals due to fungal infection) contamination of rice and corn samples and its relationship with the rate of esophageal cancer (EC) in a high risk area in northeastern Iran geographical subdivisions of Golestan province were measured by TL and HPL chromatographies. The mean level of FB1 and the proportions of FB1 contaminated samples were compared between low and high EC-risk areas of the province, respectively even found high levels of correlations between FB1 contamination in rice and the risk of EC.…”

Section: Resultsmentioning

confidence: 99%

A Study on Relativities of T-Toxin and Fumonisin in Wheat Flours in Iran

Nosrati

2015

Int J Life Sci

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Article InformationWheat is one of the most important grains consumed in the world. Food contamination with toxigenic moulds increased attention over the last three decades, which impact on food safety. Fumonisins, the TCs and ZEA are hazardous for human and animal health during normal food processing, therefore, a rapid and sensitive technique for routine assay of mycotoxins in foods is necessary. Attention to this subject that bread is one of the most widely used food substances in cereal series, it is important to continue to monitor the occurrence of these mycotoxins in cereals and cereal products. Since Fusarium species are commonly associated with cereals can produce several secondary toxic metabolites the samples collected from provincial premier and preparation of cell extracts then toxin estimation were done by ELISA (Kits and Rida Screen T-toxin/Fumonisin analysis R-Bio-Pharm GmbH) on the samples so that T-toxin/Fumonisin to be analyzed. According to the amount of fusarium toxins measured in grain and fluor samples comparing to the amount of toxin observed in bread flour maintain compliance found that the amount of FT/FFum (NPar-Wilcoxon Signed Ranks Test for F tox -FFum; Z; -2.480a, Asymp-Sig; 0.013, Pearson Correlation ;0.266, Sig;0.358) for T-toxin correlations in wheat flour incomparison have no significant correlation despite reverse relations for the both, but not statistically significant was supporting by the Pearson statistical determinations a significant correlation for the two variables incontrast were statisticaly meaningfull in numerical differences (P<0/05 ). The determinative pollutions of wheat flour samples were in the Mean; 28.764 ppb, Range; 30.100 (Min; 11.100, Max; 41.200 ppb), Var; 65.922, Std. Dev.; 8.119, Skewness; -0.614, Kurtosis; 0.590 for T toxin and for Fumonisin (Mean; 21.422 ppb, Range; 5.670 (Min; 19.290,Max; 24.960 ppb),Var; 2.623,Std.Dev.; 1.620;Skewness; 0.712, Kurtosis; 0.209) as Statistic definitions were showed a considerable disalignmented correlation specialy at a Pearson Correlation; 0.408/0.266, Sig; 0.358, Sig; 0.001-0.013 values. Thus according to the standard values for feed and food could be serious attention to the cumulative effects of toxins, a serious risk and that should not be overlooked about the cities and provinces where conducted .The maximum values of found respectively were more than standards 50% up to 100%, so a serious risk are considered.

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Fumonisin B1 Contamination of Cereals and Risk of Esophageal Cancer in a High Risk Area in Northeastern Iran

Cited by 114 publications

References 28 publications

Dietary mycotoxins, co-exposure, and carcinogenesis in humans: Short review

Dietary mycotoxins, co-exposure, and carcinogenesis in humans: Short review

Esophageal Cancer in Golestan Province, Iran: A Review of Genetic Susceptibility and Environmental Risk Factors

A Study on Relativities of T-Toxin and Fumonisin in Wheat Flours in Iran

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