Fumonisin B1 inhibits mitochondrial respiration and deregulates calcium homeostasis—Implication to mechanism of cell toxicity

Novel function of ceramide for regulation of mitochondrial ATP release in astrocytes

“…Likewise, there is discrepancy in the literature with respect to the effect of FB1 on mitochondria. FB1 has been shown to protect cells from apoptosis by reducing the effect of ceramide on mitochondria, but is has also been described to inhibit mitochondrial complex I and induce cell death (93)(94)(95). This discrepancy may be due to different FB1 concentrations and incubation times as well as the limitation that in many of the previous studies, the effect of FB1 by guest, on May 11, 2018 www.jlr.org…”

Interaction of aflatoxin B1and fumonisin B1in mice causes immunotoxicity and oxidative stress: Possible protective role using lactic acid bacteria

“…The mechanisms used by each of these two mycotoxins to induce ROS has become clearer in recent years (Domijan & Abramov, 2011). Furthermore, it has been suggested that the oxidative damage induced by AFB 1 and FB 1 might indirectly lead to mutagenicity or geno-toxicity (Stockmann-Juvala et al, 2004;Hassan et al, 2010).…”

Lipid peroxidation is essential for phospholipase C activity and IP3 related calcium signal

“…Mixed cultures of hippocampal, cortical or midbrain neurones and glial cells were prepared as described previously (Domijan and Abramov, 2011). Cultures were maintained at 37˚C in a humidified atmosphere of 5% CO 2 and 95% air for a minimum of 12 days before experimental use to ensure the expression of receptors.…”