Función pancreática exocrina en diabetes mellitus: Determinación de elastasa fecal

Abstract

One third of this group of diabetic patients had decreased levels of fecal elastase, that was associated with the time of evolution of diabetes. Patients with lower levels of elastase have significantly more steatorrhea. Among diabetics it is possible to find a group of patients with non diagnosed chronic pancreatitis.

Pancreatic Exocrine Insufficiency among Diabetic Patients

“…In a different study by Larger et al (12) involving 195 T1D patients, 34% were found to have PEI. In other researches, the percentages of PEI in diabetic patients type 1 using FEC were from 20 % to 74% (12)(13)(14)(15)(16)(17) . However, another study by Vujasinovic et al (18) was different and showed a very low prevalence of PEI of 6% in T1D.…”

“…There are conflicting reports on the association between FEC and BMI. Whereas a less series showed a relation between FEC and BMI, a few studies failed to reveal any association (12,14,15,24) .…”

¿Es la pancreatitis crónica una enfermedad rara en Chile?: ¿Subdiagnóstico, baja prevalencia o ambos?

“…Se registró la historia de pancreatitis aguda. La función exocrina se evaluó con la determinación de elastasa fecal, que se realizó mediante técnica de Elisa (Schebo Biotech, Giessen, Alemania) 7 . El valor normal de la elastasa fecal es sobre 200 µg/g de deposición, niveles entre 100 y 200 µg/g representan insuficiencia exocrina moderada y menores de 100 µg/g demuestran insuficiencia severa.…”

“…Es posible encontrar pacientes con PC entre los diabéticos. En efecto, hace 10 años estudiamos la función pancreática exocrina en un grupo de 70 diabéticos 7 . Dos pacientes fueron previamente excluidos por pesquisar en ellos alteraciones morfológicas compatibles con PC avanzada.…”

Prevalence of diabetes mellitus secondary to pancreatic diseases (type 3c)

“…A high percentage of exocrine pancreatic insufficiency has been reported for diabetic subjects. Taken together, about every second patient with type 1 diabetes mellitus (26–74%) and about every third patient with type 2 diabetes mellitus (28–36%) suffers from exocrine pancreatic insufficiency according to the available literature . Furthermore, exocrine pancreatic insufficiency seems to have a high prevalence in the general population according to non‐invasive measurement of exocrine pancreas function .…”