Function and Application of Flavonoids in the Breast Cancer

Park, Min Yeong; Kim, Yoonjung; Ha, Sang Eun; Kim, Hun Hwan; Bhosale, Pritam Bhagwan; Abusaliya, Abuyaseer; Jeong, Se Hyo; Kim, Gon Sup

doi:10.3390/ijms23147732

Cited by 15 publications

(9 citation statements)

References 112 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Root ethanolic extract's cytotoxic ability is caused by the content of existing metabolites such as flavonoids, tannins, saponins, and terpenoids. Several studies have shown that flavonoids can be developed as chemotherapy agents against breast cancer because they can treat cancer cells by targeting their anticancer effects, such as inhibiting cell growth, protein kinase activity, and inducing apoptosis (Park, et al, 2022;Magne Nde, et al, 2015;Şöhretoğlu, et al, 2021). Many natural terpenoid compounds have been shown to significantly inhibit proliferation, migration, apoptotic resistance, tumor angiogenesis or metastasis in different breast cancer cells/tumors in vitro and in vivo (Ateba, et al, 2018).…”

Section: Discussionmentioning

confidence: 99%

Antioxidant and Anticancer Activity of Dillenia serrata Thunb Ethanol Extract Against MCF-7 Breast Cancer Cell Line

Rahmawati¹,

Zulkifli²,

Nuringtyas³

et al. 2022

Indones J Cancer Chemoprevent

View full text Add to dashboard Cite

Women’s breast cancer incidence rate in Indonesia ranks number one with 12 per 100,000 cases, with luminal A as the dominant subtype. Currently, chemotherapeutic agents have limitations that lead to inefficiencies in therapy, therefore it is necessary to develop more effective and efficient chemopreventive agents. Plant secondary metabolites can provide pharmacological effects that can be used as chemoprevention agents. Secondary metabolites of D. serrata may have pharmacological effects as antioxidants and cytotoxic. This study aims to determine the antioxidant properties and cytotoxic activity of D. serrata ethanolic extract on the MCF-7 breast cancer cell line. The leaves of D. serrata were macerated, while the bark and root samples were refluxed with 96% ethanol as solvent. All extracts were evaporated with a rotary evaporator. Qualitative evaluation of the phytochemical content of leaf ethanolic extract, bark ethanolic extract, and root ethanolic extract was done using the standard tube test method. The antioxidant assay was carried out using the DPPH. The cytotoxic activity was determined in vitro using an MTT assay against the MCF-7 cell line with a series of concentrations from 12.5–400 μg/mL. Doxorubicin was the positive control treated at a 3.125–100 μg/mL concentration. The antioxidant activity showed that leaf extract had the highest antioxidant activity, followed by root and bark extract, with IC50 values of 95.66, 270.5, and 335.96 ppm, respectively. Leaf ethanolic extract and root ethanolic extract’s cytotoxic ability is considered moderate cytotoxic with IC50 values of 493.17 and 229.82 μg/mL, respectively. Amongst the ethanolic extract from the leaf, bark, and root of D. serrata, the leaf ethanolic extract has the best anti-oxidant activity and the bark ethanolic extract was the most cytotoxic one against MCF-7 cells.Keywords: Antioxidant, Cytotoxic, Dillenia serrata, MCF-7.

show abstract

Section: Discussionmentioning

confidence: 99%

Antioxidant and Anticancer Activity of Dillenia serrata Thunb Ethanol Extract Against MCF-7 Breast Cancer Cell Line

Rahmawati¹,

Zulkifli²,

Nuringtyas³

et al. 2022

Indones J Cancer Chemoprevent

View full text Add to dashboard Cite

show abstract

“…22,23 Flavonoid mampu menurunkan proliferasi sel serta meningkatkan aktivitas apoptosis sel kanker payudara. 24 Vitexin merupakan penanda pada tanaman F.deltoidea yang menunjukkan efek sitotoksik pada sel kanker payudara, ovarium dan prostat dengan mekanisme menginduksi apoptosis. 25 Vitexin dapat menurunkan ekspresi beclin-1 atau protein autofag (ATG)5 pada sel HCT-116DR.…”

Section: Efek Anti Kanker Ficus Deltoideaunclassified

Potensi Ekstrak Daun Ficus deltoidea Jack sebagai Anti Kanker Payudara

Putri,

Kusmardi,

Hakim

2024

J Indon Med Assoc

View full text Add to dashboard Cite

Kanker payudara merupakan kanker yang paling banyak didiagnosis di seluruh dunia pada tahun 2020, diikuti oleh kanker paru-paru, kolorektal, prostat, dan perut. Sebanyak 2,3 juta kasus kanker payudara terjadi atau 11,7% dari 18,1 juta total keseluruhan kasus kanker di dunia. Pada tahun 2040, kasus kanker payudara diperkirakan akan meningkat menjadi 3 juta kasus per tahun. Pada tahun 2020, di Indonesia, jumlah kasus kanker payudara mencapai 68.858 kasus (16,6%) dari total 396.914 kasus kanker yang terjadi. Angka kejadian dan kematian akibat kanker payudara masing-masing adalah 44 dan 15,3 per 100.000 penduduk di Indonesia.

show abstract

“…They trigger programmed cell death within cancer cells, leading to their elimination. Notably, their ability to trigger apoptosis through both intrinsic and extrinsic pathways underscores their significant therapeutic potential (Park et al, 2022).…”

Section: Inducing Apoptosismentioning

confidence: 99%

Most Known Citrus L. Species and Breast Cancer Relationship

Yakıncı,

Süntar

2024

Journal of Gazi University Health Sciences Institute

View full text Add to dashboard Cite

The genus Citrus L. belongs to the Rutaceae family of flowering plants and shrubs. Citrus genus has valuable edible fruits such as oranges, lemons, grapefruits, pomelos, and limes. Australia, Melanesia, Southeast Asia, East Asia, and South Asia are the native habitats of the genus Citrus. Indigenous societies in these regions have long utilized and tamed various Citrus species. Citrus fruits and their secondary metabolites have been reported to be useful agents in numerous studies to possess anti-inflammatory, antioxidant, and anticancer properties. This review gives an overview of Citrus species and background information on the potential anticancer properties of the compounds identified, along with the related in vitro and in vivo research. Studies from the past have revealed a variety of biological functions that Citrus compounds can regulate, such as angiogenesis, apoptosis, metastasis, cell cycle regulation, and cell proliferation. These promising data call for more investigation into the chemopreventative activity of Citrus and phytoconstituents.

show abstract

Function and Application of Flavonoids in the Breast Cancer

Cited by 15 publications

References 112 publications

Antioxidant and Anticancer Activity of Dillenia serrata Thunb Ethanol Extract Against MCF-7 Breast Cancer Cell Line

Antioxidant and Anticancer Activity of Dillenia serrata Thunb Ethanol Extract Against MCF-7 Breast Cancer Cell Line

Potensi Ekstrak Daun Ficus deltoidea Jack sebagai Anti Kanker Payudara

Most Known Citrus L. Species and Breast Cancer Relationship

Contact Info

Product

Resources

About