Function and energy-rich phosphate content of the hypertrophied ventricle after global ischemia and reperfusion

Fenchel, G; Storf, R.; Hoffmeister, H. E.; Heller, W.

doi:10.1007/978-3-662-11374-5_12

Cited by 5 publications

(2 citation statements)

References 34 publications

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“…4,5 There are, however, clinical and experimental data that indicate an impaired tolerance to ischemia in hypertrophied hearts. [20][21][22][23][24][25][26][27][28][29][30][31][32] This could be related to abnormalities in the coronary vasculature and ischemic injury before the ischemic arrest,28-32 to the effects of ventricular fibrillation at the onset or during ischemia, [33][34][35] or to biochemical or other metabolic alterations in hypertrophic myocardium. 36 These and other published data indicate considerable variation in the susceptibility of hypertrophic hearts to ischemic injury.…”

mentioning

confidence: 99%

Tolerance of the hypertrophic heart to ischemia. Studies in compensated and failing dog hearts with pressure overload hypertrophy.

Gaasch¹,

Zile²,

Hoshino³

et al. 1990

Circulation

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mentioning

confidence: 99%

Tolerance of the hypertrophic heart to ischemia. Studies in compensated and failing dog hearts with pressure overload hypertrophy.

Gaasch¹,

Zile²,

Hoshino³

et al. 1990

Circulation

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“…After initiation of the perfusion, adjacent tissues was dissected from the heart. A modified Langendorff technique with oxygenated Krebs-Henseleit bicarbonate buffer saline solution, as described previously, was used for retrograde perfusion with a temperature of 37~ [15]. The buffer was gassed with O2/CO 2 (95%/5%).…”

Section: Introductionmentioning

confidence: 99%

High energy phosphates in postischemic myocardium with reduced or normalized function

Hoffmeister¹,

Beyer²,

Fenchel³

et al. 1995

Int J Angiol

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Tolerance of myocardium of aged animals to repeated oxygen deficiency

Hoffmeister

Seipel

1992

Basic Res Cardiol

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Hemodynamic and metabolic effects of three times 4 min of oxygen deficiency were investigated in 18-month-old rats in comparison to 4-month-old Wistar rats. Left-ventricular isovolumic-pressure-generating capacity and dp/dtmax during isovolumic conditions and hemodynamic indices during intact circulation were determined in open-chest rats. Additionally, high-energy phosphates were measured at the end of the experiments after 20 min of postasphyxial recovery. Older rats had a significantly reduced isovolumic left-ventricular pressure generating capacity (236 +/- 9 vs 269 +/- 5 mm Hg; p less than 0.05) and a low cardiac index (55 +/- 9 vs 117 +/- 8 ml x min-1 x kg-1). The effects of the oxygen deficiency were comparable in both groups. The isovolumic pressure generating capacity was reduced for 11% vs 14%, and dp/dtmax for 13% vs 13%. The myocardial ATP-content was also decreased for the same extent in both groups (0.6 vs 1.0 mumol/gww). Both hemodynamic and biochemical results indicate that aged myocardium does not have a reduced tolerance to repeated periods of oxygen deficiency.

show abstract

Function and energy-rich phosphate content of the hypertrophied ventricle after global ischemia and reperfusion

Cited by 5 publications

References 34 publications

Tolerance of the hypertrophic heart to ischemia. Studies in compensated and failing dog hearts with pressure overload hypertrophy.

Tolerance of the hypertrophic heart to ischemia. Studies in compensated and failing dog hearts with pressure overload hypertrophy.

High energy phosphates in postischemic myocardium with reduced or normalized function

Tolerance of myocardium of aged animals to repeated oxygen deficiency

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