Function and Regulation of Protein Kinase D in Oxidative Stress: A Tale of Isoforms

Cobbaut, Mathias; Lint, Johan Van

doi:10.1155/2018/2138502

Cited by 34 publications

(31 citation statements)

References 99 publications

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“…If such an environment persists in the bone marrow, the H2O2 excess generated by malignant cells could disturb normal hematopoiesis. This aspect is supported by proofs according to which cells within the non-malignant population from patients with myeloid leukemia show signs of OxS (COBBAUT & al [36]).…”

Section: Ros Production and The Consequences Of Oxs In Myeloid Diseasementioning

confidence: 87%

The Involvement of Oxidative Stress in Chronic Myeloid Leukemia

Pascu¹,

Găman²,

Moisă³

et al. 2020

Rom Biotechnol Lett.

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In the past decades, the involvement of reactive oxygen species (ROS) in health and disease has been intensely studied. Apart from their antimicrobial role in phagocytosis, ROS are also involved in a multitude of cellular processes, such as cell cycle progression, cellular motility or amplification of signaling factors. Many diseases are characterized by an overproduction of ROS or by deficient antioxidant systems, thus leading to oxidative stress (OxS) onset. The involvement of OxS in several types of solid cancers (prostate cancer, breast cancer, colorectal cancer and melanoma) and hematological malignancies (acute lymphoblastic leukemia, myelodysplastic syndromes, acute and chronic myeloid leukemia) has been proved. Recent studies have hypothesized that ROS derived from tumors can promote cell survival, migration, metastasis, proliferation and even drug-resistance according to the origin of the cancer. However, the involvement of OxS in carcinogenesis is far from being completely understood.

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Section: Ros Production and The Consequences Of Oxs In Myeloid Diseasementioning

confidence: 87%

The Involvement of Oxidative Stress in Chronic Myeloid Leukemia

Pascu¹,

Găman²,

Moisă³

et al. 2020

Rom Biotechnol Lett.

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“…PKDs are activated by extracellular signals transduced by hormones, growth factors, cytokines, and neurotransmitters [38]. DAG in cell membranes recruits PKD through its C1 domains and induces conformational changes that abrogate PKDs autoinhibitory mechanism, leads to autophosphorylation at C-terminus of PKD1 and PKD2, and subsequently activates PKDs [2,42]. Next, DAG-activated PKC phosphorylates serine residues in the PKDs activation loop located in the kinase domain, which in turn causes further conformational changes resulting in the maximal increase of catalytic activity of PKDs [38].…”

Section: Pkdsdownstream Effectors Of Pkcs and Dagmentioning

confidence: 99%

Diacylglycerol-evoked activation of PKC and PKD isoforms in regulation of glucose and lipid metabolism: a review

et al. 2020

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Protein kinase C (PKC) and Protein kinase D (PKD) isoforms can sense diacylglycerol (DAG) generated in the different cellular compartments in various physiological processes. DAG accumulates in multiple organs of the obese subjects, which leads to the disruption of metabolic homeostasis and the development of diabetes as well as associated diseases. Multiple studies proved that aberrant activation of PKCs and PKDs contributes to the development of metabolic diseases. DAG-sensing PKC and PKD isoforms play a crucial role in the regulation of metabolic homeostasis and therefore might serve as targets for the treatment of metabolic disorders such as obesity and diabetes.

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“…Interestingly, PKD null alleles male, but not female fly, were slightly shorter lived and starvation sensitive [ 40 ]. In mammal, PKCδ activated PKD1 in response to phospholipase D activation signals on the mitochondrial membrane, and further inhibited mitochondrial depolarization and reduced the release of cytochrome C, thereby protecting cells from apoptosis and generally preventing oxidative damage [ 41 ]. Similarly, Q8SX43 is involved in oxidation-reduction process and tissue regeneration.…”

Section: Discussionmentioning

confidence: 99%

Comparative proteomics analysis of dietary restriction in Drosophila

Gao

Zhu

et al. 2020

PLoS ONE

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To explore the underlying mechanism of dietary restriction (DR) induced lifespan extension in fruit flies at protein level, we performed proteome sequencing in Drosophila at day 7 (young) and day 42 (old) under DR and ad libitum (AL) conditions. A total of 18629 unique peptides were identified in Uniprot, corresponding to 3,662 proteins. Among them, 383 and 409 differentially expressed proteins (DEPs) were identified from comparison between DR vs AL at day 7 and 42, respectively. Bioinformatics analysis revealed that membrane-related processes, post-transcriptional processes, spliceosome and reproduction related processes, were highlighted significantly. In addition, expression of proteins involved in pathways such as spliceosomes, oxidative phosphorylation, lysosomes, ubiquitination, and riboflavin metabolism was relatively higher during DR. A relatively large number of DEPs were found to participate in longevity and age-related disease pathways. We identified 20 proteins that were consistently regulated during DR and some of which are known to be involved in ageing, such as mTORC1, antioxidant, DNA damage repair and autophagy. In the integration analysis, we found 15 genes that were stably regulated by DR at both transcriptional as well as translational levels. Our results provided a useful dataset for further investigations on the mechanism of DR and aging.

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Function and Regulation of Protein Kinase D in Oxidative Stress: A Tale of Isoforms

Cited by 34 publications

References 99 publications

The Involvement of Oxidative Stress in Chronic Myeloid Leukemia

The Involvement of Oxidative Stress in Chronic Myeloid Leukemia

Diacylglycerol-evoked activation of PKC and PKD isoforms in regulation of glucose and lipid metabolism: a review

Comparative proteomics analysis of dietary restriction in Drosophila

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