Function of brain-derived neurotrophic factor in the hypothalamus: Implications for depression pathology

Autry, Anita E.

doi:10.3389/fnmol.2022.1028223

Cited by 10 publications

(4 citation statements)

References 138 publications

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“…These brain areas are known to be involved in reward-related reinforcement learning that leads to behavioral changes [ 114 ] . High levels of BDNF and its main receptor TrkB have been found across hypothalamic nuclei, including the SCN [ 115 – 116 ] . BDNF has been suggested to mediate beneficial effects of exercise and intermittent fasting on cognitive functions [ 53 ] .…”

Section: Bdnf Controls the Access For Photic Input In The Scnmentioning

confidence: 99%

Irisin/BDNF signaling in the muscle-brain axis and circadian system: A review

Inyushkin,

Poletaev,

Inyushkina

et al. 2024

J Biomed Res

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In mammals, the timing of physiological, biochemical and behavioral processes over a 24-h period is controlled by circadian rhythms. To entrain the master clock located in the suprachiasmatic nucleus of the hypothalamus to a precise 24-h rhythm, environmental zeitgebers are used by the circadian system. This is done primarily by signals from the retina via the retinohypothalamic tract, but other cues like exercise, feeding, temperature, anxiety, and social events have also been shown to act as non-photic zeitgebers. The recently identified myokine irisin is proposed to serve as an entraining non-photic signal of exercise. Irisin is a product of cleavage and modification from its precursor membrane fibronectin type Ⅲ domain-containing protein 5 (FNDC5) in response to exercise. Apart from well-known peripheral effects, such as inducing the "browning" of white adipocytes, irisin can penetrate the blood-brain barrier and display the effects on the brain. Experimental data suggest that FNDC5/irisin mediates the positive effects of physical activity on brain functions. In several brain areas, irisin induces the production of brain-derived neurotrophic factor (BDNF). In the master clock, a significant role in gating photic stimuli in the retinohypothalamic synapse for BDNF is suggested. However, the brain receptor for irisin remains unknown. In the current review, the interactions of physical activity and the irisin/BDNF axis with the circadian system are reconceptualized.

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Section: Bdnf Controls the Access For Photic Input In The Scnmentioning

confidence: 99%

Irisin/BDNF signaling in the muscle-brain axis and circadian system: A review

Inyushkin,

Poletaev,

Inyushkina

et al. 2024

J Biomed Res

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“…Badirudi burmuinetik eratorritako faktore neurotrofikoa (BDNF; Brain-Derived Neurotrophic Factor) estresaren substratu molekularra izan daitekeela, estresa pairatzen duten pertsonetan bere adierazpena murriztua dagoela aurkitu delako [53,54]. Halaber, BDNF depresioaren arrisku-faktore garrantzitsua kontsideratzen da eta bere mailak gutxituak aurkitu dira egoera hau pairatzen duten gizakietan [55][56][57].…”

Section: Estresa Depresio Nagusia Eta Sistema Neurotrofikoaunclassified

Isolamendu soziala, estres kronikoa eta depresioa

Mendoza

2023

EKAIA

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Ingurumen-estimulu batek garuneko neurokimikan aldaketak eragin ditzake, koadro neuropsikiatrikoak eraginez. Ildo horretan, isolamendu sozialak eragindako bakardade-sentimenduek estres kronikoaren egoera eragin dezakete, eta horrek aldaketa neuroendokrinoak eta immunologikoak eragiten ditu. Aldaketa horiek serotonina gutxitzea eragin lezakete, depresioa eraginez. Artikulu honetan, gizarte-isolamenduak eragindako depresioaren neurobiologian izandako aurrerapenak deskribatzen dira.

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“…Furthermore, it has been demonstrated that apoptotic elements, which are considered responsible for manifestations linked to the pathophysiology of AD, interact with various signaling molecules, including BDNF/TrkB, and downstream signaling pathways [6]. Also, clinical and preclinical research demonstrates that the alteration of BDNF/TrkB-mediated signaling is involved in the pathology of depression [7].…”

Section: Introductionmentioning

confidence: 99%

An Interaction between Brain-Derived Neurotrophic Factor and Stress-Related Glucocorticoids in the Pathophysiology of Alzheimer’s Disease

Numakawa,

Kajihara

2024

IJMS

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Both the brain-derived neurotrophic factor (BDNF) and glucocorticoids (GCs) play multiple roles in various aspects of neurons, including cell survival and synaptic function. BDNF and its receptor TrkB are extensively expressed in neurons of the central nervous system (CNS), and the contribution of the BDNF/TrkB system to neuronal function is evident; thus, its downregulation has been considered to be involved in the pathogenesis of Alzheimer’s disease (AD). GCs, stress-related molecules, and glucocorticoid receptors (GRs) are also considered to be associated with AD in addition to mental disorders such as depression. Importantly, a growing body of evidence suggests a close relationship between BDNF/TrkB-mediated signaling and the GCs/GR system in the CNS. Here, we introduce the current studies on the interaction between the neurotrophic system and stress in CNS neurons and discuss their involvement in the pathophysiology of AD.

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Function of brain-derived neurotrophic factor in the hypothalamus: Implications for depression pathology

Cited by 10 publications

References 138 publications

Irisin/BDNF signaling in the muscle-brain axis and circadian system: A review

Irisin/BDNF signaling in the muscle-brain axis and circadian system: A review

Isolamendu soziala, estres kronikoa eta depresioa

An Interaction between Brain-Derived Neurotrophic Factor and Stress-Related Glucocorticoids in the Pathophysiology of Alzheimer’s Disease

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