Function of longitudinal бvs�� circular muscle fibers in esophageal peristalsis, deduced with mathematical modeling

Brasseur, James G.; Nicosia, Mark A.; Pal, Anupam; Miller, Larry S.

doi:10.3748/wjg.v13.i9.1335

Cited by 62 publications

(56 citation statements)

References 22 publications

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“…They are well suited to studying the dynamics of the ureter. However, the development of intestinal flow models for studying the effect of single and multiple wave trains on transport requires an active wall model that can accommodate more realistic geometry and non-linear wall mechanics.More recently detailed computational models of oesophageal motility [10,11] have helped to define relationships between motility and flow. In addition CFD models have started to consider the effect of peristaltic motor patterns in the small intestine [12] and the stomach [13,14].…”

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confidence: 99%

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Investigating the relationships between peristaltic contraction and fluid transport in the human colon using Smoothed Particle Hydrodynamics

Sinnott¹,

Cleary²,

Arkwright³

et al. 2012

Computers in Biology and Medicine

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The gastrointestinal tract comprises of several distinct organs in sequence, extending over 7 meters in the human abdomen. Controlled propulsion and mixing of content along the digestive tract is essential for a normal life. This is achieved by a rich assortment of motor patterns that ensure that movements and propulsion are appropriate for the breakdown of food, absorption of nutrients and excretion of waste. These movements (motility) are due to coordinated contractions and relaxations of circular and longitudinal smooth muscle layers. For oesophageal FGIDs the combined technical advances in recording abnormal contractility, via oesophageal manometry, and relating these abnormalities to impaired flow [2] has seen a dramatic improvement in our understanding of the problem and therefore our ability to treat the patient.However, this is not the case for FGIDs in regions below the stomach. The small and large intestines are relatively inaccessible and obtaining detailed manometric recordings and visualizing the movement of digesta is difficult. As a result our understanding of normal pressure/flow relationships is still relatively simplistic [3]. Therefore while abnormal contractility is implicated in , how these abnormalities relate to impaired flow remains largely unknown.Computational modeling of gastrointestinal systems has the potential to help understand these complex relationships. Many mathematical models of peristaltic pumping in flexible tubes have been developed over the last decades and the reader is referred to [7,8] for comprehensive reviews of 3/37 this research. The vast majority of these models do not take into account the solid wall mechanics of the flexible tube in predicting the transient wall deformation. Instead the wall shape is fully prescribed. Some exceptions to this include Carew and Pedley [9] who developed a model of peristaltic flow in the ureter with an active contracting wall coupled to the internal resistance from the intra-luminal pressures in an infinitely long tube. Such models are based on lubrication theory and are therefore limited to simple geometry systems with low inertial flows and long waves. They are well suited to studying the dynamics of the ureter. However, the development of intestinal flow models for studying the effect of single and multiple wave trains on transport requires an active wall model that can accommodate more realistic geometry and non-linear wall mechanics.More recently detailed computational models of oesophageal motility [10,11] have helped to define relationships between motility and flow. In addition CFD models have started to consider the effect of peristaltic motor patterns in the small intestine [12] and the stomach [13,14]. While these studies in the stomach and small bowel have sourced anatomically accurate wall geometries from MRI, they have not attempted a 2-way coupling of the motor activity in the wall with the fluid content.Instead motor patterns are prescribed as a sequence of fixed geometric changes to the boundary.Physiologically real...

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confidence: 99%

“…More recently detailed computational models of oesophageal motility [10,11] have helped to define relationships between motility and flow. In addition CFD models have started to consider the effect of peristaltic motor patterns in the small intestine [12] and the stomach [13,14].…”

mentioning

confidence: 99%

Investigating the relationships between peristaltic contraction and fluid transport in the human colon using Smoothed Particle Hydrodynamics

Sinnott¹,

Cleary²,

Arkwright³

et al. 2012

Computers in Biology and Medicine

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“…Manometry is the gold standard for the diagnosis of motility diseases in the esophagus [2] . It has been used for many decades, and provides an indirect picture of the motility patterns because it only gives information about muscle contraction or radial squeeze [3] . However, any contraction -strong or weak -will only be measured by manometry if it occludes the measuring catheter.…”

Section: Introductionmentioning

confidence: 99%

Axial force measurement for esophageal function testing

Gravesen¹,

Funch‐Jensen²,

Gregersen³

et al. 2009

WJG

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The esophagus serves to transport food and fluid from the pharynx to the stomach. Manometry has been the "golden standard" for the diagnosis of esophageal motility diseases for many decades. Hence, esophageal function is normally evaluated by means of manometry even though it reflects the squeeze force (force in radial direction) whereas the bolus moves along the length of esophagus in a distal direction. Force measurements in the longitudinal (axial) direction provide a more direct measure of esophageal transport function. The technique used to record axial force has developed from external force transducers over in-vivo strain gauges of various sizes to electrical impedance based measurements. The amplitude and duration of the axial force has been shown to be as reliable as manometry. Normal, as well as abnormal, manometric recordings occur with normal bolus transit, which have been documented using imaging modalities such as radiography and scintigraphy. This inconsistency using manometry has also been documented by axial force recordings. This underlines the lack of information when diagnostics are based on manometry alone. Increasing the volume of a bag mounted on a probe with combined axial force and manometry recordings showed that axial force amplitude increased by 130% in contrast to an increase of 30% using manometry. Using axial force in combination with manometry provides a more complete picture of esophageal motility, and the current paper outlines the advantages of using this method.

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“…Previous modelling and experimental studies on the multi-layered oesophagus indicated that the GI tract must be simulated as multi-layered composite structures during modelling analysis (Liao et al , 2004bYang et al 2007a). By using the advanced ultrasonographic technology, it is now possible to distinguish the layered structures of the GI organs in vivo (Nicosia et al 2001;Gasser et al 2006;Brasseur et al 2007). Furthermore, the multimodal probe developed by our group can record the luminal pressure and luminal crosssectional area (CSA) simultaneously on several GI organs.…”

Section: (A ) Mechanical Properties Of the Gi Tissuesmentioning

confidence: 99%

Biomechanical functional and sensory modelling of the gastrointestinal tract

Liao

Lelic

Gao

et al. 2008

Phil. Trans. R. Soc. A.

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The aim of this review is to describe the biomechanical, functional and sensory modelling work that can be used to integrate the physiological, anatomical and medical knowledge of the gastrointestinal (GI ) system. The computational modelling in the GI tract was designed, implemented and evaluated using a series of information and communication technologies-based tools. These tools modelled the morphometry, biomechanics, functions and sensory aspects of the human GI tract. The research presented in this review is based on the virtual physiological human concept that pursues a holistic approach to representation of the human body. Such computational modelling combines imaging data, GI physiology, the gut-brain axis, geometrical and biomechanical reconstruction, and computer graphics for mechanical, electronic and pain analysis. The developed modelling will aid research and ensure that medical professionals benefit through the provision of relevant and precise information about a patient's condition. It will also improve the accuracy and efficiency of the medical procedures that could result in reduced cost for diagnosis and treatment.

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Function of longitudinal бvs�� circular muscle fibers in esophageal peristalsis, deduced with mathematical modeling

Cited by 62 publications

References 22 publications

Investigating the relationships between peristaltic contraction and fluid transport in the human colon using Smoothed Particle Hydrodynamics

Investigating the relationships between peristaltic contraction and fluid transport in the human colon using Smoothed Particle Hydrodynamics

Axial force measurement for esophageal function testing

Biomechanical functional and sensory modelling of the gastrointestinal tract

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