Function of Myocardial Contraction and Relaxation in Essential Hypertension in Dynamics of Acupuncture Therapy

Radzievsky, S.A.; Lebedeva, O D; Fisenko, L A; Majskaja, S.A.

doi:10.1142/s0192415x89000188

Cited by 14 publications

(6 citation statements)

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“…As early as the 1950's, acupuncture was shown to reduce BP in hypertensive patients [7,26,35]. Radzievsky et al [21] confirmed that in hypertensive patients acupuncture exerts a stable hypotensive effect, improves contractile function and reverses myocardial hypertrophy. Williams et al [32] found that EA induces a significant immediate post-stimulation shortterm reduction of diastolic BP.…”

Section: Introductionmentioning

confidence: 99%

Inhibitory effect of electroacupuncture (EA) on the pressor response induced by exercise stress

2004

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We examined the effect of EA on the exercise stress-induced pressor response in healthy adult subjects of both sexes. Each subject was subjected to a bicycle exercise test using a ramp protocol once/week for three or four weeks. Subjects were asked to perform the following tests in random order: 1) a baseline exercise test without EA and 2) exercise after acupuncture at P 5-6, LI 4-L 7 and/or G 37-39 acupoints. Brachial systolic (SBP), diastolic (DBP), and mean blood pressures (MBP), heart rate (HR) and the rate-pressure product (RPP, systolic BP x HR/100) were measured every three min, while a 12 lead ECG was monitored continuously. We observed increases in MBP, SBP, HR and RPP in all 17 subjects during exercise. In 12 of the 17 subjects (71 %), EA for 30 min before exercise, either at Jianshi-Neiguan acupoints (P 5-6) or Hegu-Lique acupoints (LI 4-L 7), led to an increase in maximal workload, and reduced peak SBP, MBP and RPP responses to exercise; EA did not alter DBP or HR responses in these subjects. EA at control acupoints (Guangming-Xuanzhong acupoints, G 37-39) in five subjects did not alter the hemodynamic responses. Seven additional subjects were enrolled to study the effect of EA during a bicycle exercise test using a constant workload. The results were similar, in five of the seven subjects SBP, MBP and RPP after exercise were attenuated significantly by EA at P 5-6. We conclude that EA at specific acupoints improves exercise capacity and reduces the hemodynamic responses in approximately 70% of normal subjects.

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Section: Introductionmentioning

confidence: 99%

Inhibitory effect of electroacupuncture (EA) on the pressor response induced by exercise stress

2004

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“…There has been increasing interest in the western countries in exploring alternative medicinal treatments and in considering new therapies like acupuncture for cardiovascular disease. A number of small clinical reports suggest that acupuncture may reduce BP in hypertension patients (9,21,31). A study from our laboratory in animals showed that electroacupuncture (EA) alleviates experimental reflex-induced hypertension and myocardial ischemia (7).…”

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confidence: 99%

Excitatory projections from arcuate nucleus to ventrolateral periaqueductal gray in electroacupuncture inhibition of cardiovascular reflexes

Li¹,

Tjen‐A‐Looi²,

Longhurst³

2006

American Journal of Physiology-Heart and Circulatory Physiology

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Excitatory projections from arcuate nucleus to ventrolateral periaqueductal gray in electroacupuncture inhibition of cardiovascular reflexes. Am J Physiol Heart Circ Physiol 290: H2535-H2542, 2006. First published January 6, 2006 doi:10.1152/ajpheart.00972.2005We have shown that the modulatory effect of electroacupuncture (EA) on the blood pressure (BP) response induced by visceral organ stimulation is related to inhibition of cardiovascular neurons in the rostral ventrolateral medulla (rVLM) through a mechanism that involves opioids. This effect is long lasting and may involve a long-loop neural supraspinal pathway, including the arcuate nucleus (ARC), which is an important site of opioid neurotransmitter synthesis. Therefore, we evaluated the role of the hypothalamic ARC and its interaction with the midbrain ventrolateral periaqueductal gray (vlPAG) in the EA-BP response. The gallbladder of ␣-chloralose-anesthetized cats was stimulated to test for the influence of EA on splanchnic afferent-induced cardiovascular reflexes. Electrodes were placed around the splanchnic nerve (SN), and acupuncture needles were applied at P5-6 acupoints overlying the median nerve (MN). Electrophysiological recordings showed that spontaneous activity of ARC and vlPAG neurons was low (1.3 Ϯ 0.5 and 2.0 Ϯ 0.5 spikes/s, respectively). We observed a gradation of responses of ARC neurons to the stimulation of different acupoints, ranging from uniform responses of all neurons during stimulation of the P5-6, LI4-11, H5-6, and St2-G2 located over deep nerves to fewer responses during stimulation of LI6-7 and G37-39 located over superficial nerves. Microinjection of the excitatory amino acid DL-homocysteic acid (DLH 4 nM, 50 nl) into the ARC augmented the responses of vlPAG neurons, whereas microinjection of kainic acid (KA 1 mM, 50 nl) to deactivate neurons in the ARC decreased vlPAG responses to SN stimulation. Thirty minutes of EA at P5-6 increased the SN-evoked discharge of vlPAG neurons (7.0 Ϯ 1.2 to 14.3 Ϯ 3.0 spikes/30 stimuli), a response that was blocked by microinjection of KA into the ARC. Microinjection of DLH into the ARC, like EA, inhibited (30 min) the reflex increase in BP induced by application of bradykinin (BK) to the gallbladder, whereas microinjection of KA into the ARC blocked the inhibitory influence of EA at P5-6 on the BK-induced BP response. These results suggest that excitatory projections from the ARC to the vlPAG are essential to the EA inhibition of the reflex increase in BP induced by SN or gallbladder visceral afferent stimulation. blood pressure response; splanchnic nerve; somatic nerve; acupoint; DL-homocysteic acid; kainic acid CARDIOVASCULAR DISEASE is the greatest cause of death in middle-aged and elderly North Americans and Europeans (32). There has been increasing interest in the western countries in exploring alternative medicinal treatments and in considering new therapies like acupuncture for cardiovascular disease. A number of small clinical reports suggest that acupuncture may reduce BP in hyperte...

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“…Since 1950, some studies have reported that acupuncture can be used to reduce BP in hypertensive patients [21e23]. Radzievsky et al [24] confirmed that acupuncture plays a role in regulating BP, improves the contractile function, and reverses the myocardium hypertrophy in patients with hypertension. Richter et al [12] determined with the use of an electrocardiogram that acupuncture can prevent myocardial ischemia in patients with coronary heart disease.…”

Section: Discussionmentioning

confidence: 99%

Effects of Acupuncture at the Yintang and the Chengjiang Acupoints on Cardiac Arrhythmias and Neurocardiogenic Syncope in Emergency First Aid

Fabrin

Soares

Yoshimura

et al. 2016

Journal of Acupuncture and Meridian Studies

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This study evaluated the effectiveness of YinTang and ChengJiang acupoints on patients with cardiac arrhythmia and neurocardiogenic syncope in emergency first aid. A 45 year old woman underwent acupuncture. She had a previous history of a valvuloplasty for rheumatic disease and two acute myocardial infarctions, followed by four catheterizations and an angioplasty. Needling of the YinTang acupoint and stimulation of the ChengJiang acupoint through acupressure were performed for 20 minutes soon after syncope and during tachycardia, hypertension, tachypnea, and precordial pain, without any effect on peripheral oxygen saturation (SpO2) or the glycemic index. Data were analyzed comparatively by using the following parameters at rest, during syncope, and at 1 minute and 10 minutes after an emergency acupuncture procedure: blood pressure; heart rate; SpO2; and respiratory rate. We found that acupuncture at YinTang and ChenJiang acupoints induced cardiovascular responses, increased the limits of the body's homeostasis, and normalized the patient's condition in the case of syncope. Acupuncture using a combination of ChengJiang and YinTang acupoints had an immediate effect on the autonomic nervous system and on maintaining homeostasis and energy balance in the body. Although this technique was effective, the patient was still referred to the Emergency Room.

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Function of Myocardial Contraction and Relaxation in Essential Hypertension in Dynamics of Acupuncture Therapy

Cited by 14 publications

References 0 publications

Inhibitory effect of electroacupuncture (EA) on the pressor response induced by exercise stress

Inhibitory effect of electroacupuncture (EA) on the pressor response induced by exercise stress

Excitatory projections from arcuate nucleus to ventrolateral periaqueductal gray in electroacupuncture inhibition of cardiovascular reflexes

Effects of Acupuncture at the Yintang and the Chengjiang Acupoints on Cardiac Arrhythmias and Neurocardiogenic Syncope in Emergency First Aid

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