Functional abdominal pain disorders and asthma: two disorders, but similar pathophysiology?

Kumari, Manori Vijaya; Amarasiri, Lakmali; Rajindrajith, Shaman; Devanarayana, Niranga Manjuri

doi:10.1080/17474124.2020.1821652

Cited by 2 publications

(3 citation statements)

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“…27 The possible explanation is a low-grade inflammation in the gut and dysregulated immune activation on the epithelial barrier in children with allergic diseases resulting in barrier defect and increased risk for dysmotility and visceral hypersensitivity. 28 Many studies have reported an increase rate of psychosocial problems including presence of anxiety and depressive disorders, stress and traumatic life events in children with FAPDs. [3][4][5] Although a lower parental education level, separated parental status, recent death of a close family member and larger family size have been reported to be associated with FAPDs.…”

Section: Discussionmentioning

confidence: 99%

“…A birth cohort study has shown that allergy‐related diseases as well as sensitisation to food allergens are associated with an increased risk of FAPDs, and the risk increases with the number of diagnosed allergy‐related diseases 27 . The possible explanation is a low‐grade inflammation in the gut and dysregulated immune activation on the epithelial barrier in children with allergic diseases resulting in barrier defect and increased risk for dysmotility and visceral hypersensitivity 28 …”

Section: Discussionmentioning

confidence: 99%

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Prevalence of functional abdominal pain disorders and functional constipation in adolescents

Siajunboriboon

Tanpowpong

Empremsilapa

et al. 2022

J Paediatrics Child Health

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Aim: Functional abdominal pain disorders (FAPDs) and functional constipation (FC) are the common functional gastrointestinal disorders in adolescents. We aimed to determine the prevalence of FAPDs and FC in adolescents using the Rome IV Questionnaire of Pediatric Gastrointestinal Symptoms and the factors associated with these two functional gastrointestinal disorders. Methods: A survey for the prevalence of FAPDs and FC in adolescents was carried out at two high schools. A translated and validated Thai version of Rome IV Questionnaire of Pediatric Gastrointestinal Symptoms was used. Potential associated factors were also collected. Psychosocial problems were evaluated by using the Strengths and Difficulties Questionnaire. Results: A total of 1700 adolescents (55.5% females) with a mean age (SD) of 16.1 (0.9) years were enrolled. The prevalence of FAPDs and FC was 5.3% and 8.1%, respectively. The subtypes of FAPDs were functional dyspepsia (4.7%; postprandial distress syndrome 3.9% and epigastric pain syndrome 0.8%), irritable bowel syndrome (0.6%), abdominal migraine (0.4%) and functional abdominal pain not otherwise specified (0.3%). Multiple logistic regression analysis revealed that FAPDs were associated with female gender (odds ratio (OR) 3.3, 95% confidence interval (CI): 1.7-6.4), underlying allergic diseases (OR 3.2, 95% CI: 1.6-6.6) and concomitant emotional problem (OR 2.7, 95% CI: 1.2-5.9). No significant associated factors with FC were found. Conclusion: FAPDs and FC are common in adolescents. Postprandial distress syndrome is the most common subtype of FAPD. Associated factors for FAPDs may suggest hormonal, immune-related and psychological involvement in the disease pathogenesis.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Prevalence of functional abdominal pain disorders and functional constipation in adolescents

Siajunboriboon

Tanpowpong

Empremsilapa

et al. 2022

J Paediatrics Child Health

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“…Several studies have demonstrated the association between IBS and asthma in children and adults [ 8 , 9 ]. However, the exact pathophysiological mechanisms that could explain this association have not been elucidated [ 10 ]. Therefore, the main objective of this study was to find a possible pathophysiological mechanism to explain this association between asthma and FAPDs.…”

Section: Introductionmentioning

confidence: 99%

Gastric motility and pulmonary function in children with functional abdominal pain disorders and asthma: A pathophysiological study

et al. 2022

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Background An association has been shown between functional abdominal pain disorders (FAPDs) and asthma. However, the exact reason for this association is obscured. The main objective of this study is to identify the possible underlying pathophysiological mechanisms for the association between FAPDs and asthma using gastric motility and lung function tests. Methods This was a cross-sectional comparative study that consisted of four study groups. Twenty-four children (age 7–12 years) each were recruited for four study groups; asthma only, FAPDs only, both asthma and FAPDs, and healthy controls. Asthma was diagnosed using the history and bronchodilator reversibility test. The diagnosis of FAPDs was made using Rome IV criteria. All subjects underwent ultrasound assessment of gastric motility and pulmonary function assessment by spirometry, using validated techniques. Results All gastric motility parameters, gastric emptying rate, amplitude of antral contraction, and antral motility index, were significantly impaired in children with FAPDs only, children with asthma only, and children with both asthma & FAPDs, compared to controls (p<0.05). Pulmonary function parameters indicating airway obstruction (FEV1/FVC ratio, peak expiratory flow rate, FEF25-75%) were not impaired in children with FAPDs only compared to controls (p>0.05), but significantly impaired in children with asthma and children with both disorders. Antral motility index correlated with the FEV1/FVC ratio (r = 0.60, p = 0.002) and FEF25%-75% (r = 0.49, p = 0.01) in children with both asthma and FAPDs. Conclusions Gastric motor functions were significantly impaired in children with asthma, children with FAPDs, and children with both disorders. Motility index, measuring overall gastric motor activity, showed a significant positive correlation with lung function parameters that measure airflow limitation. Therefore, these diseases might arise as a result of primary disturbance of smooth muscle activity in the airways and gastrointestinal wall, which could be a possible pathophysiological mechanism for this association between asthma and FAPDs.

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Functional abdominal pain disorders and asthma: two disorders, but similar pathophysiology?

Cited by 2 publications

References 219 publications

Prevalence of functional abdominal pain disorders and functional constipation in adolescents

Prevalence of functional abdominal pain disorders and functional constipation in adolescents

Gastric motility and pulmonary function in children with functional abdominal pain disorders and asthma: A pathophysiological study

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