Functional activity of 5-HT4 receptors in children with congenital heart disease

Abstract

The effect of 5-methoxytryptamine (5-HT(4) receptor agonist) on the inotropic function of atrial myocardium was studied in children aged 2 months to 17 years, operated on for congenital heart disease. Functional activity of 5-HT(4) receptors was 8.4 times higher in dysfunction of the atrial septum in comparison with other congenital heart diseases. The positive inotropic effects of 5-HT(4) receptor agonist can promote compensation of myocardial work in children with pathological circulation.

Increased Concentrations of Serotonin and 5-Hydroxyindoleacetic Acid in Blood Plasma from Patients with Pulmonary Hypertension due to Mitral Valve Disease

“…The plasma and platelets in some tubes were frozen at -80 o C until further study. The concentrations of 5-HT and its metabolite (5-HIAA) in the plasma and platelets were measured by high-performance liquid chromatography with electrochemical detection [2].…”