Functional Activity of the Corpus Luteum Following Hysterectomy¹

Cloprostenol-induced luteolysis in the marmoset monkey (Callithrix jacchus)

“…In many non-primates the luteolytic factor originates from the uterus and there is considerable evidence to support the concept that prostaglandin (PG) F-2ce is the uterine factor responsible for luteolysis in laboratory and farm animals (Poyser, 1981). It seems unlikely that an identical mecha¬ nism is responsible for terminating the secretory activity of the primate corpus luteum in view of the failure of hysterectomy to prolong luteal function in the rhesus monkey (Neill, Johansson & Knobil, 1969) and man (Beling, Marcus & Markham, 1970). The hypothesis that endogenous PGs, possibly of ovarian origin, may nevertheless be involved in luteolysis in primates is supported by the findings that some exogenous PGs have luteolytic properties in man and monkeys (Korda, Shutt, Smith, Shearman & Lyneham, 1975;McCracken, Einer-Jensen & Fried, 1979; Vickery, McRae & Bajka, 1979 ;Wilks, 1983).…”

Prostaglandin E-2-9-ketoreductase in ovarian tissues

“…PGF-2ais now believed to be the uterine luteolytic agent in most species except primates (see Horton & Poyser, 1976, for review). Human luteal function appears to be independent of uterine control since neither hysterectomy (Beling, Marcus & Markham, 1970) nor congenital absence of Fallopian tubes, uterus and vagina (Fraser, Baird, Hobson, Michie & Hunter, 1973) disrupt cyclic ovarian function. PGF-2a in vitro, however, in cultured human granulosa cells (McNatty, Henderson & Sawers, 1975), or directly injected into the human ovary (Korda, Shutt, Smith, Shearman & Lyneham, 1975) reduces progesterone secretion, suggesting a possible intraovarian role for in man.…”

The Effects of Uterine Artery Embolisation and Surgical Treatment on Ovarian Function in Women With Uterine Fibroids

“…This study and others 34 have emphasised the importance of the role of a viable uterus, or an intact blood supply, on normal ovarian function. Several mechanisms have been proposed in an attempt to explain the apparent change in ovarian function after UAE.…”