Functional Activity of the Liver during Severe Compression Injury

Abstract

Severe compression injury in rats was accompanied by metabolic acidosis, cytolytic syndrome, disturbances in liver excretory function and detoxification, and change in biotransformation processes.

Comparative efficiency of succinate-containing antihypoxants in traumatic toxicosis

“…Traumatic toxicosis was induced in 68 male Wistar rats by 4-h compression of soft tissues of the hip in a special clamp of 5 cm 2 area with a U-shaped incision to prevent the femoral bone fracture [4]. All the studied antihypoxants were intraperitoneally injected to animals (groups of 10-12 rats) directly after decompression in the optimal effective doses: 10 ml/kg reamberine, 1.5 ml/kg cytofl avin (both drugs manufactured by Polisan), 25 mg/ml metaprot plus (Antiviral), and 25 mg/kg compound BM-616 (synthesized at Department of Pharmacology, S. M. Kirov Military Medical Academy).…”

“…Material for the study was collected 12 h after decompression. The protective effect of antihypoxants in traumatic toxicosis was evaluated by blood levels of urea, uric acid, creatinine, and potassium ions, measured by standard kits, and by the rate of bromosulfaleine (BSF) elimination from circulating blood [4]. Retention of BSF was calculated by the formula:…”

“…Of these, prospective cytoprotectors are succinate-containing drugs. Their high therapeutic effi ciency was shown in metabolic disorders of different origin [3,4,6,11]. The armory of succinate-containing antihypoxants is not large.…”

“…The most interesting of the new prospective compounds are 2-amino-4-acetylthiasolo [5,4-b]indole succinaminic acid (BM-616 compound) and 2-ethylthiobenzimidasole with succinic acid (Metaprot plus). Their extensive pharmacological activities were shown in many diseases, including toxic involvement of the liver [4].…”