“…Similarly in Medicago truncatula, silencing of Mkb1 (E3 ubiquitin ligase), that control the activity of HMGR results in accumulation of monoglycosylated saponins (Moses et al 2014a, b). This enzyme was characterized in different plants including Hevea brasiliensis (Chye et al 1991), potato (Bhattacharyya et al 1995), wheat (Aoyagi et al 1993), Camptotheca acuminate (Maldonado-Mendoza et al 1997), mulberry (Jain et al 2000), rice (Ha et al 2001), Capsicum annuum (Ha et al 2003), Ginkgo biloba (Shen et al 2006), Corylus avellana , Euphorbia pekinensi (Cao et al 2010), Salvia miltiorrhiza (Dai et al 2011), coffee (Tiski et al 2011), Glycyrrhiza uralensis (Rong et al 2011), Withania somnifera (Akhtar et al 2013), Dendrobium officinale (Zhang et al 2014a, b), Paris fargesii , Centella asiatica (Kalita et al 2015), Arabidopsis (Suzuki et al 2004), Cyanotis arachnoidea (Wang et al 2014a, b, c) and Panax ginseng (Kim et al 2014).…”