Functional analysis of −351 interleukin-9 promoter polymorphism reveals an activator controlled by NF-κB

Early, Stephen V.; Huyett, Phillip; Brown-Steinke, Kathleen; Borish, Larry; Steinke, John W.

doi:10.1038/gene.2009.28

Cited by 11 publications

(8 citation statements)

References 36 publications

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“…Each sub-type of T CD4+ affords protection, in general, to different types of infection [ 33 ]. NF-κB has been described as a crucial component in many of these sub-types of polarization (Th1, Th2, Th17, Th9) [ 34 , 35 , 36 , 37 , 38 , 39 ]. Box 1 summarizes the diverse effects of NF-κB on the immune system.…”

Section: The Role Of Nf-κb In Physiology Inflammation and Cancermentioning

confidence: 99%

NF-kappaB: Two Sides of the Same Coin

Pires

Silva

Ferreira

et al. 2018

Genes

187

156

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Nuclear Factor-kappa B (NF-κB) is a transcription factor family that regulates a large number of genes that are involved in important physiological processes, including survival, inflammation, and immune responses. More recently, constitutive expression of NF-κB has been associated with several types of cancer. In addition, microorganisms, such as viruses and bacteria, cooperate in the activation of NF-κB in tumors, confirming the multifactorial role of this transcription factor as a cancer driver. Recent reports have shown that the NF-κB signaling pathway should receive attention for the development of therapies. In addition to the direct effects of NF-κB in cancer cells, it might also impact immune cells that can both promote or prevent tumor development. Currently, with the rise of cancer immunotherapy, the link among immune cells, inflammation, and cancer is a major focus, and NF-κB could be an important regulator for the success of these therapies. This review discusses the contrasting roles of NF-κB as a regulator of pro- and antitumor processes and its potential as a therapeutic target.

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Section: The Role Of Nf-κb In Physiology Inflammation and Cancermentioning

confidence: 99%

NF-kappaB: Two Sides of the Same Coin

Pires

Silva

Ferreira

et al. 2018

Genes

187

156

View full text Add to dashboard Cite

show abstract

“…These results suggest that the noncanonical NF-κB pathway via the RelB:p52 heterodimer might be important in Th9 differentiation. Finally, it has been suggested that IL-9 expression in T cells is regulated by NF-κB, thereby implicating the pathway in the function of these cells (58). While many questions concerning the Th9 subset of CD4 + T cells remain unanswered, these findings represent the first steps towards a better understanding of the development and function of Th9 cells.…”

Section: Nf-κb In Th9 Developmentmentioning

confidence: 99%

NF‐κB: roles and regulation in different CD4⁺ T‐cell subsets

Ghosh

2013

Immunological Reviews

343

264

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Summary The nuclear factor-κB (NF-κB) family of transcription factors plays important roles in various biological processes including apoptosis, stress response, immunity, and inflammation. NF-κB signaling is involved in both immune cell development and function, and it is critical in modulation of the immune response through the transcriptional regulation of cytokine and chemokine expression. An area of great interest in T-cell-mediated adaptive immunity is the ability of naive CD4+ T cells generated in the thymus to differentiate into various subsets including T-helper 1 (Th1), Th2, Th17, Th9, follicular helper T (Tfh), Th22 and regulatory T (Treg) cells, upon encountering different pathogens and microenvironments. In this review, we discuss the role of NF-κB pathway in the development and functional divergence of the different helper T-cell subsets as well as in regulatory T cells.

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“…[7][8][9] Recent findings in the field have contributed to elucidate key molecular and cellular events involved not only in healthy immune response to allergens but also in breaking-tolerance to allergens or restoration of appropriate immune responses to allergens after AIT. [10][11][12][13][14][15][16][17] In this context, it is now well accepted that the generation and preservation of functional allergen-specific Treg cells are essential for healthy immune responses to allergens and successful AIT. [18][19][20] Treg cells comprise different subsets with suppressive capacity able to inhibit the initiation and development of allergic diseases and allergic patients seem to exhibit a specific impairment in the generation of regulatory T cells.…”

Section: Introductionmentioning

confidence: 99%

Regulatory T cells and immune regulation of allergic diseases: roles of IL-10 and TGF-β

et al. 2014

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The prevalence of allergic diseases has significantly increased in industrialized countries. Allergen-specific immunotherapy (AIT) remains as the only curative treatment. The knowledge about the mechanisms underlying healthy immune responses to allergens, the development of allergic reactions and restoration of appropriate immune responses to allergens has significantly improved over the last decades. It is now well-accepted that the generation and maintenance of functional allergen-specific regulatory T (Treg) cells and regulatory B (Breg) cells are essential for healthy immune responses to environmental proteins and successful AIT. Treg cells comprise different subsets of T cells with suppressive capacity, which control the development and maintenance of allergic diseases by various ways of action. Molecular mechanisms of generation of Treg cells, the identification of novel immunological organs, where this might occur in vivo, such as tonsils, and related epigenetic mechanisms are starting to be deciphered. The key role played by the suppressor cytokines interleukin (IL)-10 and transforming growth factor (TGF)-β produced by functional Treg cells during the generation of immune tolerance to allergens is now well established. Treg and Breg cells together have a role in suppression of IgE and induction of IgG4 isotype allergen-specific antibodies particularly mediated by IL-10. Other cell types such as subsets of dendritic cells, NK-T cells and natural killer cells producing high levels of IL-10 may also contribute to the generation of healthy immune responses to allergens. In conclusion, better understanding of the immune regulatory mechanisms operating at different stages of allergic diseases will significantly help the development of better diagnostic and predictive biomarkers and therapeutic interventions.

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Functional analysis of −351 interleukin-9 promoter polymorphism reveals an activator controlled by NF-κB

Cited by 11 publications

References 36 publications

NF-kappaB: Two Sides of the Same Coin

NF-kappaB: Two Sides of the Same Coin

NF‐κB: roles and regulation in different CD4⁺ T‐cell subsets

Regulatory T cells and immune regulation of allergic diseases: roles of IL-10 and TGF-β

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Functional analysis of −351 interleukin-9 promoter polymorphism reveals an activator controlled by NF-κB

Cited by 11 publications

References 36 publications

NF-kappaB: Two Sides of the Same Coin

NF-kappaB: Two Sides of the Same Coin

NF‐κB: roles and regulation in different CD4+ T‐cell subsets

Regulatory T cells and immune regulation of allergic diseases: roles of IL-10 and TGF-β

Contact Info

Product

Resources

About

NF‐κB: roles and regulation in different CD4⁺ T‐cell subsets