Functional analysis of Group III afferent fibres of mammalian muscles

Paintal, A. S.

doi:10.1113/jphysiol.1960.sp006486

Cited by 322 publications

(180 citation statements)

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“…Although the perceived pain levels appeared to be sufficient (Figure 2), whether other characteristics of this EKP pain are representative is unknown. Previous authors [47][48][49][50] supported the idea that EKP induced by hypertonic saline is representative of joint pain related to knee injury. Investigators 47 have reported that the nature, quality, and distribution of pain elicited by hypertonic saline is similar to clinical anterior knee joint pain.…”

Section: Discussionmentioning

confidence: 49%

“…Investigators 47 have reported that the nature, quality, and distribution of pain elicited by hypertonic saline is similar to clinical anterior knee joint pain. Also, results 49,50 from animal experiments suggest that group III and IV nociceptive afferents are active due to hypertonic saline, providing more evidence that the pathways involved in EKP are similar to musculoskeletal pain. Researchers 48 have also reported that hypertonic saline induces the release of substance P from C-fiber neurons, which is consistent with musculoskeletal pain.…”

Section: Discussionmentioning

confidence: 96%

See 1 more Smart Citation

A Novel Experimental Knee-Pain Model Affects Perceived Pain and Movement Biomechanics

Seeley

Park

King

et al. 2013

Journal of Athletic Training

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Context: Knee injuries are prevalent, and the associated knee pain is linked to disability. The influence of knee pain on movement biomechanics, independent of other factors related to knee injuries, is difficult to study and unclear.Objective: (1) To evaluate a novel experimental knee-pain model and (2) better understand the independent effects of knee pain on walking and running biomechanics.Design: Crossover study. Setting: Biomechanics laboratory.Patients or Other Participants: Twelve able-bodied volunteers (age ¼ 23 6 3 years, height ¼ 1.73 6 0.09 m, mass ¼ 75 6 14 kg).Intervention(s): Participants walked and ran at 3 time intervals (preinfusion, infusion, and postinfusion) for 3 experimental conditions (control, sham, and pain). During the infusion time interval for the pain and sham conditions, hypertonic or isotonic saline, respectively, was continuously infused into the right infrapatellar fat pad for 22 minutes.Main Outcome Measure(s): We used repeated-measures analyses of variance to evaluate the effects of time and condition on (1) perceived knee pain and (2) key biomechanical characteristics (ground reaction forces, and joint kinematics and kinetics) of walking and running (P , .05).Results: The hypertonic saline infusion (1) increased perceived knee pain throughout the infusion and (2) reduced discrete characteristics of each component of the walking ground reaction force, walking peak plantar-flexion angle (range ¼ 628-678), walking peak plantar-flexion moment (range ¼ 95-104 NÁm), walking peak knee-extension moment (range ¼ 36-49 NÁm), walking peak hip-abduction moment (range ¼ 62-73 NÁm), walking peak support moment (range ¼ 178-207 NÁm), running peak plantar-flexion angle (range ¼ 388-778), and running peak hip-adduction angle (range ¼ 5-218).Conclusions: This novel experimental knee pain model consistently increased perceived pain during various human movements and produced altered running and walking biomechanics that may cause abnormal knee joint-loading patterns.

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Section: Discussionmentioning

confidence: 49%

Section: Discussionmentioning

confidence: 96%

A Novel Experimental Knee-Pain Model Affects Perceived Pain and Movement Biomechanics

Seeley

Park

King

et al. 2013

Journal of Athletic Training

View full text Add to dashboard Cite

show abstract

“…II-III-and IV-afferents activate intrafusal muscle fibres via gamma-and beta efferent pathways. III-and IV-afferents have been observed inside the muscle spindle (Paintal, 1960, Stacey, 1969. If inflammatory and pain metabolites are concentrated intrafusally, III-and IV-afferents, which comprise also chemical and pain receptors, may activate gamma-and beta-efferent activity via spinal reflex pathway.…”

Section: Discussion Of the Discrepancies Of "Integrated Hypothesis" Amentioning

confidence: 99%

Electromyography in Myofascial Syndrome

Partanen¹

2012

EMG Methods for Evaluating Muscle and Nerve Function

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“…Removal of substances which accumulate into the gel-filled periaxial space of the muscle spindle is a slow process. The sensory innervation of a muscle spindle consists of primary and secondary endings [13], and also IIIand IV-afferents [16][17][18][19]. Also, autonomic innervation has been observed [19,20].…”

Section: Structure Vascular Supply and Innervation Of The Muscle Spimentioning

confidence: 99%