Functional Analysis of the Bradyrhizobium japonicum Regsr Two-Component Regulatory System

Emmerich, Ralf; Strehler, Philipp; Bauer, Evelyne; Fischer, Hans‐Martin; Hennecke, Hauke

doi:10.1007/0-306-47615-0_31

Cited by 2 publications

(1 citation statement)

References 6 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It has been reported that RegA homologues from B. japonicum (RegR) and S. meliloti (ActR) also function as activators of cbb operons in concert with CbbR (27,32). Thus, as was demonstrated for R. capsulatus, RegA homologues appear to control CO 2 fixation in a number of photosynthetic and nonphotosynthetic bacteria.…”

Section: Carbon Fixationmentioning

confidence: 90%

RegB/RegA, a Highly Conserved Redox-Responding Global Two-Component Regulatory System

Elsen

Swem

et al. 2004

Microbiol Mol Biol Rev

195

236

View full text Add to dashboard Cite

SUMMARY The Reg regulon from Rhodobacter capsulatus and Rhodobacter sphaeroides encodes proteins involved in numerous energy-generating and energy-utilizing processes such as photosynthesis, carbon fixation, nitrogen fixation, hydrogen utilization, aerobic and anaerobic respiration, denitrification, electron transport, and aerotaxis. The redox signal that is detected by the membrane-bound sensor kinase, RegB, appears to originate from the aerobic respiratory chain, given that mutations in cytochrome c oxidase result in constitutive RegB autophosphorylation. Regulation of RegB autophosphorylation also involves a redox-active cysteine that is present in the cytosolic region of RegB. Both phosphorylated and unphosphorylated forms of the cognate response regulator RegA are capable of activating or repressing a variety of genes in the regulon. Highly conserved homologues of RegB and RegA have been found in a wide number of photosynthetic and nonphotosynthetic bacteria, with evidence suggesting that RegB/RegA plays a fundamental role in the transcription of redox-regulated genes in many bacterial species.

show abstract

Section: Carbon Fixationmentioning

confidence: 90%

RegB/RegA, a Highly Conserved Redox-Responding Global Two-Component Regulatory System

Elsen

Swem

et al. 2004

Microbiol Mol Biol Rev

195

236

View full text Add to dashboard Cite

show abstract

RegB/RegA, A Global Redox-Responding Two-Component System

Bauer

Advances in Experimental Medicine and Biology

View full text Add to dashboard Cite

The RegB-RegA regulon from Rhodobacter capsulatus and Rhodobacter sphaeroides encodes proteins involved in numerous energy-generating and energy-utilizing processes such as photosynthesis, carbon fixation, nitrogen fixation, hydrogen utilization, aerobic and anaerobic respiration, denitrification, electron transport and aerotaxis. The redox signal that is detected by the membrane-bound sensor kinase, RegB, has been identified to be the ubiquinone pool in the membrane. Regulation of RegB autophosphorylation also involves a redox-active cysteine that is present in the cytosolic region of RegB. Both phosphorylated and unphosphorylated forms of the cognate response regulator RegA are capable of activating or repressing a variety of genes in the regulon. Highly conserved homologues of RegB and RegA have been found in a wide number of photosynthetic and nonphotosynthetic bacteria with evidence suggesting that RegB/RegA have a fundamental role in the transcription of redox-regulated genes in many bacterial species.

show abstract

Functional Analysis of the Bradyrhizobium japonicum Regsr Two-Component Regulatory System

Cited by 2 publications

References 6 publications

RegB/RegA, a Highly Conserved Redox-Responding Global Two-Component Regulatory System

RegB/RegA, a Highly Conserved Redox-Responding Global Two-Component Regulatory System

RegB/RegA, A Global Redox-Responding Two-Component System

Contact Info

Product

Resources

About