Functional and biochemical aspects of laminaria use in first-trimester pregnancy termination

Ye, B.L.; Yamamoto, Keizô; Tyson, John E.

doi:10.1016/s0002-9378(16)32281-5

Cited by 22 publications

(8 citation statements)

References 15 publications

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“…The abortifacient effects of laminaria and Rivanol are both believed to stimulate the uterus mechanically [24,45,47], induce a synthesis or a release of prostaglandin from the decidua and the fetal membranes [25,38,46] and soften the cervix [25,37,48].…”

Section: Discussionmentioning

confidence: 99%

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Comparative Study of Cervical Laminar Tents prior to Extra-Amniotic Injection of Ethacridine Lactate (Rivanol) and a Condom-Nelathon Catheter Method for Second-Trimester Pregnancy Interruption in Vietnam

Järnbert

Klang

Vinh

et al. 1999

Gynecol Obstet Invest

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Objective: To determine whether the regimen for termination of second-trimester pregnancies using laminaria tents 12–24 h prior to extra-amniotic ethacridine lactate (Rivanol) instillation, is more effective in shortening the insertion-expulsion interval than the presently used method of abortion induction by a condom/Nelathon catheter. Design: A prospective randomised comparative study was performed at Uong Bi General Hospital in Quang Ninh Province, Vietnam, on 91 women undergoing pregnancy termination in the second trimester. Interventions: The subjects were randomly allocated to 2 treatment groups, receiving either the Nelathon catheter-condom method (n = 50) or by insertion of a laminaria tent into the cervical canal for preinduction, 13–29 h before extra-amniotic instillation of ethacridine lactate (n = 34). Seven subjects were not pretreated with the laminaria tent. Main Outcome Measures: The insertion-expulsion intervals and the incidence of side effects were assessed. Results: The mean insertion-expulsion interval in the 2 groups was not significantly different (mean 27.5 ± 16.1 and 26.4 ± 16.4 h, respectively), calculating the insertion-expulsion interval from the start of active treatment, i.e. from the instillation of Rivanol or insertion of the Nelathon catheter and condom, until expulsion of the fetus. Conclusions: The laminaria-Rivanol method for pregnancy interruption is not more advantageous than the existing Nelathon catheter-condom method. Simple, successful and cost-effective methods in achieving second-trimester abortion in the Vietnamese context have therefore to be identified and tested.

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Section: Discussionmentioning

confidence: 99%

“…One such dilatator is the laminaria tent, made from the dried stem of the seaweed Laminaria digitata or Laminaria japonica, which has been used as cervical dilatators for more than 100 years. The efficacy and safety have been described in several reports [19,[35][36][37][38][39][40][41][42][43][44][45][46].…”

Section: Introductionmentioning

confidence: 99%

Comparative Study of Cervical Laminar Tents prior to Extra-Amniotic Injection of Ethacridine Lactate (Rivanol) and a Condom-Nelathon Catheter Method for Second-Trimester Pregnancy Interruption in Vietnam

Järnbert

Klang

Vinh

et al. 1999

Gynecol Obstet Invest

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“…These findings showed positive effects in inhibiting weight gain and have promising value in preventing obesity (Matanjum et al ., 2016). Obstetrical uses: The dried stipes of Laminaria spp. have been used in obstetrical and gynaecological practices as a natural dilator of the cervix, thus making gynaecological treatment easier (Strauss et al , 1979; Ye et al ., 1982). Laminaria was found to be particularly effective in intrauterine devices (IUD) for birth control (Manabe et al ., 1982).…”

Section: Pharmaceutical Importance Of Seaweedsmentioning

confidence: 99%

“…have been used in obstetrical and gynaecological practices as a natural dilator of the cervix, thus making gynaecological treatment easier (Strauss et al, 1979;Ye et al, 1982). Laminaria was found to be particularly effective in intrauterine devices (IUD) for birth control (Manabe et al, 1982).…”

Section: Pharmaceutical Importance Of Seaweedsmentioning

confidence: 99%

Potential of marine algae (sea weeds) as source of medicinally important compounds

Anand

Rachel

Thangaraju

et al. 2016

Plant Genet. Resour.

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Scientific research has always been concerned with aspects of human health. There are several systems of medicines besides the globally accepted allopathy, which are based on compounds originating from natural products. Recent research has been centred around validation of the traditional knowledge on medicinal products. The traditional systems in India, China and forklore medicines in other parts of the world have indicated the potential of natural products consist of various chemical compounds that could be used as drugs. The search for drugs against five major dreadful diseases namely, cancer, AIDS, heart disease, diabetes and pulmonary disorders that attack the present day human from natural products has been in progress for some time. Microbes, plants and animals are the sources of natural products. In the past five decades, the research on bioactive chemicals from marine algae has been incited and several compounds with biological activity were isolated from algae. Generally, these are secondary metabolites produced for chemical defence against the biotic pressure of predators, consumers and epibionts. These potential drugs are now attracting considerable attention from the pharmaceutical industries due to the necessity of identifying substances that could be utilized for novel therapeutic purposes. Several compounds such as alginate, carrageenans, sulphated and halogenated polysachcharise and other derivatives have been shown to provide drugs that could be antiviral, anticancer and antimicrobial. The present account is on the potential of marine macro-algae for medicinally important products.

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“…prostaglandins [! ]• To evaluate the effect of the unloaded A rod, a study was made comparing the A rod with laminaria, a dilator that has been shown to have a good effect on widening the cervix in previous studies [2][3][4][5][6].…”

Section: Introductionmentioning

confidence: 99%

Cervical Dilatation before First Trimester Elective Abortion: A Comparison between Laminaria and a Newly Developed Hydrogel Tent, the A Rod

Molin

Brundin²

1992

Gynecol Obstet Invest

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Functional and biochemical aspects of laminaria use in first-trimester pregnancy termination

Cited by 22 publications

References 15 publications

Comparative Study of Cervical Laminar Tents prior to Extra-Amniotic Injection of Ethacridine Lactate (Rivanol) and a Condom-Nelathon Catheter Method for Second-Trimester Pregnancy Interruption in Vietnam

Comparative Study of Cervical Laminar Tents prior to Extra-Amniotic Injection of Ethacridine Lactate (Rivanol) and a Condom-Nelathon Catheter Method for Second-Trimester Pregnancy Interruption in Vietnam

Potential of marine algae (sea weeds) as source of medicinally important compounds

Cervical Dilatation before First Trimester Elective Abortion: A Comparison between Laminaria and a Newly Developed Hydrogel Tent, the A Rod

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