“…On each cMRI image, point coordinates for P i (P i,x , P i,y , P i,z ) are computed using the specific pixel dimension of the image (i.e., 1.25× 1.25 mm), stored in the "Pixel spacing" DICOM field. Subsequently, the geometry of MV annulus is automatically reconstructed through a two-step validated procedure (32,33): (I) a cylindrical reference frame is set with the origin in the center of mass of the MV annular extracted cloud of points, and the z-axis normal to the least-square plane of the annular points; (II) in this local reference frame, the radial (ρ) and axial (h) positions of the points belonging to the annular profile ( Figure S1B, red…”