Functional and evolutionary genomics of antibiotic resistance in tuberculosis: from biology to global DR-TB control

Abstract

Antibiotic resistance and tuberculosisMechanisms and evolution of drug resistance in M. tuberculosis Genomics and drug resistance detection in tuberculosisTuberculosis comorbidities and TB-HIV coinfection OBJECTIVES OF THIS DISSERTATION CHAPTER 1 An evolutionary functional genomics approach identifies novel candidate regions involved in isoniazid resistance in Mycobacterium tuberculosisComorbidities associated with TB are conditions that occur alongside the TB infection, and can complicate treatment, cause poorer outcomes, or increase the risk of death [50]. The most common comorbidities associated with TB include HIV, diabetes, cardiovascular disease, mental health conditions, and substance use disorders. HIV is the most frequent comorbidity, and is associated with more severe TB, more frequent and longer-lasting symptoms, and