The paper considers the problems of ergonomic thinking, its formation and evolution when designing information systems in the conditions of socio-technogenic development of the world. Special attention is paid to the analysis of the ergonomic thinking evolution in the design of human-technology-environment systems. The main purpose of this work is to study the process of formation and further development of ergonomic thinking since the very beginning of ergonomics as a science. The paper considers the main approaches to the definition of ergonomic thinking, on which basis definitions are proposed that take into account all the features and directions of the evolution of ergonomic thought. Special attention is paid to the development of the main directions and factors of ergonomics according to the periods of its formation.