Functional and morphological effects of defibrotide on renal ischemia

Comandella, M. G.; Rigotti, Paolo; Valente, Marialuisa; Pittoni, G; Baldan, N; Ganz, Eric; Amodio, Piero; Ancona, E.

doi:10.1007/bf02576212

Cited by 3 publications

(1 citation statement)

References 14 publications

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“…Normothermic renal ischaemia of 60 min duration in pigs results in tubular necrosis and severe impairment of function (Haab et al 1996). The morphological and functional damage caused by 60 and even 90 min of normothermic renal ischaemia can nevertheless be attenuated by interventions such as limitation of initial reperfusion pressure (Haab et al 1996) or application of defibrotide (Comandella et al 1993). Renal normothermic ischaemia of 60 min and longer occurs during parenchymal sparing surgery for renal tumours (Campbell et al 1994;Hafez et al 1998) and thoracoabdominal aortic aneurysm repair (Schepens et al 1994) and it predisposes for postoperative acute renal failure (Campbell et al 1994).…”

Section: Critique Of Methodsmentioning

confidence: 99%

No Protection of the Porcine Kidney by Ischaemic Preconditioning

Behrends

Walz

Kribben

et al. 2000

Experimental Physiology

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One or more episodes of sublethal ischaemia and reperfusion delay infarct development during subsequent, sustained ischaemia in the heart and skeletal muscle. The present study tested whether or not such ischaemic preconditioning (IP) also protects the kidney. Enflurane‐anaesthetized pigs underwent 60 min of right renal vessel occlusion (RVO), followed by 8 h of reperfusion without (placebo group, n = 8) or with three preceding cycles of 10 min RVO and 10 min reperfusion (IP group, n = 8). After 8 h of reperfusion, kidneys were oliguric in both groups (placebo group: 23 ± 21 ml h‐1, IP group: 24 ± 27 ml h‐1). A transient polyuric phase occurred in the IP group at 2 h reperfusion. The reperfused kidneys did not excrete inulin, creatinine or urea in both groups, although renal blood flow during reperfusion was similar to baseline. Morphological damage ranged in both groups from single cell necrosis to disseminated patchy necrosis; the number of pyknotic cells tended to be higher in the IP group than in the placebo group (27.0 ± 7.1 vs. 15.6 ± 5.6%, n.s.). In anaesthetized pigs, IP did not therefore attenuate renal dysfunction and morphological damage resulting from 60 min of renal normothermic ischaemia followed by 8 h of reperfusion.

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