2014
DOI: 10.1007/s00595-014-0847-y
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Functional and pathological characteristics of reversible remodeling in a canine right ventricle in response to volume overloading and volume unloading

Abstract: PurposesPatients who undergo right ventricular (RV) outflow augmentation inevitably develop RV remodeling due to pulmonary insufficiency-related volume overload (VOL). However, the reversibility of this remodeling is not fully understood. The goal of this study was to establish an animal model of VOL and unloading to characterize the functional and pathological characteristics and reversibility of RV remodeling.MethodsVOL-RV was successfully induced by establishing direct RV-pulmonary artery (PA) bypass for 12… Show more

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Cited by 6 publications
(3 citation statements)
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“…This situation is similar to that in the LV with chronic aortic valve disease [15][16][17]. We previously reported the development of myocardial fibrosis in the canine RV in response to PRrelated volume overload [18]. The degree of RV myocardial fibrosis before PVR has the potential to predict late outcomes of RV function.…”
supporting
confidence: 61%
See 1 more Smart Citation
“…This situation is similar to that in the LV with chronic aortic valve disease [15][16][17]. We previously reported the development of myocardial fibrosis in the canine RV in response to PRrelated volume overload [18]. The degree of RV myocardial fibrosis before PVR has the potential to predict late outcomes of RV function.…”
supporting
confidence: 61%
“…Similar to the LV, chronic RV volume overload caused by PR and TR might lead to development of myocardial fibrosis in the RV in patients with repaired TOF [13,14]. Resolution of PR and TR can induce RV reverse remodeling through improvement of mitochondrial function, as demonstrated in our previous study in a canine model [18].…”
Section: Commentmentioning
confidence: 52%
“…Ishimaru et al [15] reported that RV volume overload for 12 weeks by direct RV-pulmonary artery (PA) bypass in beagle canines induced the microstructural disorganization of cardiomyocytes, and/or structural/functional deterioration of the mitochondria in the RV muscle. These changes were only partially reversed by volume unloading for 4 weeks via the bypass division.…”
Section: Discussionmentioning
confidence: 99%