2012
DOI: 10.1016/j.bcp.2012.04.011
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Functional and pharmacological characterization of a VEGF mimetic peptide on reparative angiogenesis

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Cited by 92 publications
(92 citation statements)
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“…28 In soluble form, the QK peptide has been reported to demonstrate angiogenic bioactivity above a threshold concentration of about 1 pM. 6,28,29 The QK peptide has also demonstrated bioactivity across a broad range of concentrations (1 pM-100 mM) when presented as a substrate-bound peptide on collagen scaffolds via collagenbinding peptides, 30 on hydroxyapatite via binding of an osteocalcin sequence, 29 and on self-assembled monolayers via covalent immobilization. 31 Keeping the MITCH network polymers unmodified, affinity immobilization is achieved simply by synthesizing a fusion of QK to a single proline-rich domain (P1), which acts as an affinity tag (Fig.…”
Section: Introductionmentioning
confidence: 97%
“…28 In soluble form, the QK peptide has been reported to demonstrate angiogenic bioactivity above a threshold concentration of about 1 pM. 6,28,29 The QK peptide has also demonstrated bioactivity across a broad range of concentrations (1 pM-100 mM) when presented as a substrate-bound peptide on collagen scaffolds via collagenbinding peptides, 30 on hydroxyapatite via binding of an osteocalcin sequence, 29 and on self-assembled monolayers via covalent immobilization. 31 Keeping the MITCH network polymers unmodified, affinity immobilization is achieved simply by synthesizing a fusion of QK to a single proline-rich domain (P1), which acts as an affinity tag (Fig.…”
Section: Introductionmentioning
confidence: 97%
“…Only a small number of VEGF residues are important for binding to VEGF receptors [18,25], and, therefore, several molecules able to modulate VEGF biological activities have been reported [26]. Many VEGF mimetic peptides with antiangiogenic activity have been described [27], while very few molecules with pro-angiogenic activity have been reported [28].…”
Section: Introductionmentioning
confidence: 99%
“…Therefore, the primary aim of this study was to investigate the therapeutic effectiveness of liposomal angiogenic peptides in the treatment of cerebral ischemia. To achieve this goal, the present study used angiogenic peptides instead of proteins to treat cerebral ischemia because, unlike angiogenic proteins, peptides have low production costs with no immunogenicity and are better suited for clinical use (5,6). 18 F-FDG, a glucose analog with a hydroxyl group in position 29 replaced by a positron-emitting radioactive isotope 18 F, is commonly used as a marker for tissue glucose uptake; as such, it provides a sensitive and reliable means of assessing glucose metabolism.…”
mentioning
confidence: 99%