Introduction. Carpal tunnel release (CTR) is among the most commonly performed procedures within a hand, in a day surgery setting. Studies suggest that patient concerns and emotional state may influence CTR outcomes. Aim. To determine the frequency of preoperative concerns among patients operated for carpal tunnel syndrome (CTS) and their correlation with negative emotions, socio-demographic and clinical variables. Materials and methods. A total of 72 patients (81.9% women) scheduled for CTR were included in the study. Pain, anxiety, irritability, and depression were measured using the Visual Analogue Scale (VAS) on the day of surgery. Tailor-made questionnaires were used to explore patients’ concerns and to gather socio-demographic and clinical data. Statistical analysis was performed utilizing R language. α < 0.05 was considered significant. Results. At least one concern was declared by the vast majority of patients (93.1%). Postoperative pain was the most prevalent concern, declared by 49.3% of participants. “Outcomes will not meet my expectations” was a concern for 43.3% of participants. Concern related to intraoperative complications was declared by 34.3% of participants. Patients scheduled for CTR had high mean VAS scores of anxiety and irritability and low score of depression. Anxiety reached the highest level among measured variables. Patients who declared postoperative pain had statistically significantly higher levels of pain, anxiety, irritability, and depression than patients without this concern. Concern that surgery outcomes will not meet patient’s expectations was declared statistically significantly more frequently by patients with any surgery in history. Conclusions. Preoperative concerns among patients operated for carpal tunnel syndrome are extremely prevalent. Those concerns are accompanied by a high level of negative emotions. Therefore assessment of emotional status, addressing particular concerns, and tailored preoperative intervention, all are of crucial importance. A meticulous approach to postoperative pain and patients’ expectations regarding outcomes seem to be essential. The mentioned strategy may positively influence patients’ comfort and surgery outcomes.