Functional and Structural Brain Changes Associated with Methamphetamine Abuse

Jan, Reem Kais; Kydd, Robert R.; Russell, Bruce

doi:10.3390/brainsci2040434

Cited by 39 publications

(23 citation statements)

References 196 publications

(530 reference statements)

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“…This raises the possibility that the integrity of frontal cortical brain networks implicated in the executive functions listed above might be compromised in methamphetamine-dependent patients. This concurs with evidence for metabolic, structural and functional anomalies in the middle frontal and DLPFC in chronic methamphetamine users Jan et al, 2012).…”

Section: Introductionsupporting

confidence: 89%

“…Striatal pathways project to brain regions implicated in top-down cognitive control, such as the dorsolateral prefrontal cortex (DLPFC) (Alexander et al, 1986). This concurs with evidence for metabolic, structural and functional anomalies in the middle frontal and DLPFC in chronic methamphetamine users Jan et al, 2012). This concurs with evidence for metabolic, structural and functional anomalies in the middle frontal and DLPFC in chronic methamphetamine users Jan et al, 2012).…”

Section: Introductionsupporting

confidence: 57%

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Distinct intrinsic functional brain network abnormalities in methamphetamine‐dependent patients with and without a history of psychosis

et al. 2016

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Chronic methamphetamine use is associated with executive functioning deficits that suggest dysfunctional cognitive control networks (CCNs) in the brain. Likewise, abnormal connectivity between intrinsic CCNs and default mode networks (DMNs) has also been associated with poor cognitive function in clinical populations. Accordingly, we tested the extent to which methamphetamine use predicts abnormal connectivity between these networks, and whether, as predicted, these abnormalities are compounded in patients with a history of methamphetamine-associated psychosis (MAP). Resting-state fMRI data were acquired from 46 methamphetamine-dependent patients [19 with MAP, 27 without (MD)], as well as 26 healthy controls (CTRL). Multivariate network modelling and whole-brain voxel-wise connectivity analyses were conducted to identify group differences in intrinsic connectivity across four cognitive control and three DMN networks identified using an independent components analysis approach (meta-ICA). The relationship of network connectivity and psychotic symptom severity, as well as antipsychotic treatment and methamphetamine use variables, was also investigated. Robust evidence of hyper-connectivity was observed between the right frontoparietal and anterior DMN networks in MAP patients, and 'normalized' with increased duration of treatment with antipsychotics. Attenuation of anticorrelated anterior DMN-dorsal attention network activity was also restricted to this group. Elevated coupling detected in MD participants between anterior and posterior DMN networks became less apparent with increasing duration of abstinence from methamphetamine. In summary, we observed both alterations of RSN connectivity between DMN networks with chronic methamphetamine exposure, as well as DMN-CCN coupling abnormalities consistent with possible MAP-specific frontoparietal deficits in the biasing of task-appropriate network activity.

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Section: Introductionsupporting

confidence: 89%

Section: Introductionsupporting

confidence: 57%

Distinct intrinsic functional brain network abnormalities in methamphetamine‐dependent patients with and without a history of psychosis

et al. 2016

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“…Cadet et al, 2010; Jan et al, 2012a) has prompted evaluation of chemical markers of neuronal integrity and neuroinflammation with MRS in methamphetamine users. These studies have shown lower levels of n -acetyl-aspartate (NAA) metabolites and a lower ratio of NAA to creatine and phosphocreatine (Cr) metabolites – indicating poorer neuronal integrity and viability – among methamphetamine abusers relative to healthy controls in frontal brain regions, particularly the ACC (Ernst et al, 2000; Nordahl et al, 2002; Nordahl et al, 2005; Sailasuta et al, 2010; Sung et al, 2007).…”

Section: Molecular Imaging Of Methamphetamine Usersmentioning

confidence: 99%

Chronic methamphetamine abuse and corticostriatal deficits revealed by neuroimaging

et al. 2015

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Despite aggressive efforts to contain it, methamphetamine use disorder continues to be major public health problem; and with generic behavioral therapies still the mainstay of treatment for methamphetamine abuse, rates of attrition and relapse remain high. This review summarizes the findings of structural, molecular, and functional neuroimaging studies of methamphetamine abusers, focusing on cortical and striatal abnormalities and their potential contributions to cognitive and behavioral phenotypes that can serve to promote compulsive drug use. These studies indicate that individuals with a history of chronic methamphetamine abuse often display several signs of corticostriatal dysfunction, including abnormal gray- and white-matter integrity, monoamine neurotransmitter system deficiencies, neuroinflammation, poor neuronal integrity, and aberrant patterns of brain connectivity and function, both when engaged in cognitive tasks and at rest. More importantly, many of these neural abnormalities were found to be linked with certain addiction-related phenotypes that may influence treatment response (e.g., poor self-control, cognitive inflexibility, maladaptive decision-making), raising the possibility that they may represent novel therapeutic targets.

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“…There are increasing evidences that chronic methamphetamine use was associated with abnormalities in brain morphometry, function and metabolism (Jan et al 2012;London et al 2015;Salo and Fassbender 2012). However, whether these brain abnormalities can recover with abstinence remains unclear and longitudinal studies are needed to shed lights on it.…”

Section: Introductionmentioning

confidence: 99%

Persistent Microstructural Deficits of Internal Capsule in One-Year Abstinent Male Methamphetamine Users: a Longitudinal Diffusion Tensor Imaging Study

Zhuang

Tang

Zhong

et al. 2016

J Neuroimmune Pharmacol

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White matter (WM) alterations have been reported in methamphetamine (MA) users. However, knowledge about longitudinal changes in WM during abstinence from MA remains unknown. The present study aimed to examine how WM changes in long-term MA abstinent, in particular, whether the WM deficits would recover as the duration of abstinence extended. Twenty male MA dependent individuals and 19 healthy controls (HCs) were recruited and participated in both clinical assessments and diffusion tensor imaging (DTI) scans. The MA group underwent two DTI scans, a baseline scan with a duration of abstinence of 6.4 months and and a follow-up scan with a duration of abstinence of 13.0 months. Tract-Based Spatial Statistics was utilized to conduct baseline DTI analysis of MA group compared with HCs. The clusters with significant group differences of factional anisotropy (FA) were extracted as region of interests (ROIs). Mean values of DTI measurements (FA, mean diffusivity, axial diffusivity and radial diffusivity) were calculated within the ROIs in each subject's native space at baseline and follow-up. The MA group showed significant lower FA in the right internal capsule and superior corona radiate than HCs. The deficits did not recover when the duration of abstinence from MA reached 13 months. No significant correlations were found between FA and clinical measurements. Our results suggested persistent microstructure deficits of WM tracts surrounding the basal ganglia in MA dependent individuals.

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Functional and Structural Brain Changes Associated with Methamphetamine Abuse

Cited by 39 publications

References 196 publications

Distinct intrinsic functional brain network abnormalities in methamphetamine‐dependent patients with and without a history of psychosis

Distinct intrinsic functional brain network abnormalities in methamphetamine‐dependent patients with and without a history of psychosis

Chronic methamphetamine abuse and corticostriatal deficits revealed by neuroimaging

Persistent Microstructural Deficits of Internal Capsule in One-Year Abstinent Male Methamphetamine Users: a Longitudinal Diffusion Tensor Imaging Study

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