Functional and structural brain differences in bipolar disorder: a multimodal meta-analysis of neuroimaging studies

Chen, Guanmao; Wang, Junjing; Gong, Jiaying; Qi, Zhangzhang; Fu, Siying; Tang, Guixian; Chen, Pan; Huang, Li; Wang, Ying

doi:10.1017/s0033291722002392

Cited by 30 publications

(17 citation statements)

References 119 publications

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“…For example, Wang Ying et al . observed an increase in functional function in the left middle lobe, right brain, and right upper extremity of bipolar disorder patients and a decrease in the resting activity of the crotch lobe [36]. This is analogous to our results, but there are quite opposite consequences depending on whether sample subjects, disease subtypes, drug interference, or genetic factors are interfering.…”

Section: Discussionsupporting

confidence: 88%

“…After treatment, these signals in the patient's brain and node center showed normalization [35]. Furthermore, a multimodal meta-analysis found patients with bipolar disorder displayed increased resting-state functional activity in the left middle frontal gyrus, right inferior frontal gyrus (IFG) extending to the right insula, right superior frontal gyrus and bilateral striatum, and sMRI meta-analysis showed that patients with bipolar disorder displayed decreased VBM in the right IFG extending to the right insula, STG, left superior frontal gyrus (medial prefrontal cortex), left thalamus, and right fusiform gyrus [36]. When degree centrality values in the left parahippocampal gyrus were used as a biomarker to differentiate between bipolar mania patients and healthy controls via an SVM approach, the associated accuracy (83.33%), specificity (85.51%), and sensitivity (88.41%) values suggested that reduced degree centrality values in the left parahippocampal gyrus may represent an effective biomarker of bipolar mania.…”

Section: Discussionmentioning

confidence: 99%

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Abnormal degree centrality can be a potential imaging biomarker in first-episode, drug-naive bipolar mania

Zhang

Long

et al. 2023

NeuroReport

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Brain network abnormalities in emotional response exist in bipolar mania. However, few studies have been published on network degree centrality of first-episode, drug-naive bipolar mania, and healthy controls. This study aimed to assess the utility of neural activity values analyzed via degree centrality methods. Sixty-six first-episode, drugnaive patients with bipolar mania and 60 healthy controls participated in resting-state functional magnetic resonance rescanning and scale estimating. The degree centrality and receiver operating characteristic (ROC) curve methods were used for an analysis of the imaging data. Relative to healthy controls, first-episode bipolar mania patients displayed increased degree centrality values in the left middle occipital gyrus, precentral gyrus, supplementary motor area, Precuneus, and decreased degree centrality values in the left parahippocampal gyrus, right insula and superior frontal gyrus, medial. ROC results exhibited degree centrality values in the left parahippocampal gyrus that could distinguish first-episode bipolar mania patients from healthy controls with 0.8404 for AUC. Support vector machine results showed that reductions in degree centrality values in the left parahippocampal gyrus can be used to effectively differentiate between bipolar disorder patients and healthy controls with respective accuracy, sensitivity, and specificity values of 83.33%, 85.51%, and 88.41%. Increased activity in the left parahippocampal gyrus may be a distinctive neurobiological feature of firstepisode, drug-naive bipolar mania. Degree centrality values in the left parahippocampal gyrus might be served as a potential neuroimaging biomarker to discriminate firstepisode, drug-naive bipolar mania patients from healthy controls.

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Section: Discussionsupporting

confidence: 88%

Section: Discussionmentioning

confidence: 99%

Abnormal degree centrality can be a potential imaging biomarker in first-episode, drug-naive bipolar mania

Zhang

Long

et al. 2023

NeuroReport

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“…Furthermore, we found that the connectivity between precuneus and fusiform was significantly lower in both of ADHD and BD group than HG. Precuneus and fusiform, as the core regions of default mode network (DMN) and visual processing network (VPN), showed altered resting-state functional connectivity as well as decreased grey matter in both ADHD and BD group (Chen et al, 2022; Kucyi et al, 2015; Sutcubasi et al, 2020). More specifically, the intra-network connectivity between DMN and VPN exhibited a strong contribution to emotion classification and sustained emotional experience during naturalistic contexts (Xu et al, 2023).…”

Section: Discussionmentioning

confidence: 99%

The shared and disorder-specific resting state functional connectivity associated with emotion regulation between ADHD and bipolar disorder

Zhuang,

Xu,

et al. 2024

Preprint

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BackgroundEmotion regulation deficits have been frequently observed between ADHD (Attention-deficit/hyperactivity disorder, ADHD) and BD (bipolar disorder, BD) adults, however, common and distinguishable alterations in functional connectivity during rest remain poorly understood.ObjectivesThe current study was performed to determine the shared and disorder-specific resting state functional connectivity (rsFC) features within the proposed hierarchical emotion regulation model.MethodThe whole-brain seed-to-voxel functional connectivity analyses were performed on the neuroimaging data from the OpenFMRI project included 40 ADHD adults, 49 BD adults, as well as 49 age and gender matched healthy controls.ResultsOur findings showed significantly shared and disorder-specific rsFC circuits mainly linking to the processes of emotion perception and interception during emotion regulation but not response inhibition or executive control. Such as, the results found significantly enhanced functional connectivity strength between inferior occipital gyrus (IOG)-lingual/fusiform gyrus as well as superior parietal lobule (SPL)-insula circuits in ADHD group compared to healthy group (HG) and BD group, which suggests impaired emotional facial perception and interoceptive processing in ADHD than BD adults. In addition, the connectivity between precuneus and fusiform was significantly lower in both of ADHD and BD group compared to HG and no significant difference was found between patient groups. This indicates similar neural patterns underlying the impairment in emotion classification and emotional experience for ADHD and BD adults.ConclusionsTogether these findings can promote the understanding of common and disorder-specific neural mechanism underlying emotion dysregulations and facilitate neuroimaging-based clinical evaluation for ADHD and BD adults.

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“…The authors found decreased volume in the post-central gyrus, right paracentral lobule, and left superior temporal gyrus. Chen et al [25] noted that individuals with BSDs displayed structural alterations in some areas, particularly the left superior temporal and post-central gyri. Alterations in these areas of the brain may contribute to auditory hallucinations, difficulty ascertaining the emotions of others, risk-taking, and emotional dysregulation [25].…”

Section: Stress Shift Work and Sleepmentioning

confidence: 99%

Bipolar spectrum disorders among American registered nurses: a narrative literature review

Armijo

2023

Discov Psychol

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Background Bipolar spectrum disorders (BSDs) are serious psychiatric conditions correlated with high rates of suicide, substance misuse, hospitalization, and cardiometabolic diseases. Little is known about how BSDs affect American registered nurses (RNs) diagnosed with the condition. Purpose This review aimed to identify risk factors and socioeconomic impacts influencing American RNs diagnosed with BSDs. Methods The study examined literature in PubMed, CINAHL, PsycINFO, and SCOPUS. Articles discussing RNs diagnosed with BSDs were selected and evaluated for common risk factors and socioeconomic themes. Results Eight papers meeting the inclusion criteria were analyzed. Five articles were personal narratives, two were mixed methods, and one was a cohort study. Risk factors included gender, stress, shift work, and sleep. Socioeconomic themes included economic impact and subjective experience. The female gender predominated in the RN workforce and, to a lesser extent, BSDs. Stress was intertwined with shift work and sleep, as they all influenced circadian alterations, mania, depression, and substance use. The economic impact was poorly understood; however, identified elements were related to hospitalization, absenteeism, and preclusion from insurance coverage. Subjective experiences of RNs with BSDs indicated that stigma incited hostile work environments and shame while seeking mental health care. Conclusion The findings indicated that the identified risk factors contributed to adverse psychological, neurological, and cardiometabolic outcomes. Identified socioeconomic themes suggested unfavorable outcomes, including absenteeism, exclusion from insurance coverage, stigmatization, and hospitalization. However, there is a paucity of information, especially from high-quality studies. This novel review provides the foundation for future research.

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Functional and structural brain differences in bipolar disorder: a multimodal meta-analysis of neuroimaging studies

Cited by 30 publications

References 119 publications

Abnormal degree centrality can be a potential imaging biomarker in first-episode, drug-naive bipolar mania

Abnormal degree centrality can be a potential imaging biomarker in first-episode, drug-naive bipolar mania

The shared and disorder-specific resting state functional connectivity associated with emotion regulation between ADHD and bipolar disorder

Bipolar spectrum disorders among American registered nurses: a narrative literature review

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