Functional and structural vascular adaptations following 8 weeks of low volume high intensity interval training in lower leg of type 2 diabetes patients and individuals at high risk of metabolic syndrome

Madsen, S.; Thorup, Anne Cathrine; Overgaard, Kristian; Bjerre, Mette; Jeppesen, Per Bendix

doi:10.3109/13813455.2015.1087033

Cited by 31 publications

(35 citation statements)

References 52 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…6.1 ± 1.8) in patients with T2D. In another study, Madsen et al. (2015) showed that after low‐volume HIIT, FMD increased more in healthy persons (41%) than in patients with T2D (23%).…”

Section: Discussionmentioning

confidence: 92%

“…Green, Spence, Halliwill, Cable, & Thijssen, 2011). Research in patients with T2D found that exercise training increased FMD in the brachial and popliteal artery (Francois & Little, ; Madsen, Thorup, Overgaard, Bjerre, & Jeppesen, ). Type 2 diabetes is associated with endothelial dysfunction as well as elevated retrograde SR (Gibbs et al., ).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Improved brachial artery shear patterns and increased flow‐mediated dilatation after low‐volume high‐intensity interval training in type 2 diabetes

Afousi

Izadi

Rakhshan

et al. 2018

Experimental Physiology

View full text Add to dashboard Cite

Atherosclerosis in patients with type 2 diabetes is characterized by endothelial dysfunction associated with impaired flow-mediated dilatation (FMD) and increases retrograde and oscillatory shear. The present study investigated endothelium-dependent vasodilatation and shear rate in patients with type 2 diabetes at baseline and follow-up after 12 weeks of low-volume high-intensity interval training (LV-HIIT) or continuous moderate-intensity training (CMIT). Seventy-five sedentary patients with type 2 diabetes and untreated pre- or stage I hypertension were randomly divided into LV-HIIT, CMIT and control groups. The LV-HIIT group intervention was 12 intervals of 1.5 min at 85-90% maximal heart rate (HR ) and 2 min at 55-60% HR . The CMIT group intervention was 42 min of exercise at 70% HR for three sessions per week during 12 weeks. High-resolution Doppler ultrasound was used to measure FMD, arterial diameter, anterograde and retrograde blood flow, and shear rate patterns. Brachial artery FMD increased significantly in the LV-HIIT group (3.83 ± 1.13 baseline, 7.39 ± 3.6% follow-up), whereas there was no significant increase in the CMIT group (3.45 ± 0.97 baseline, 4.81 ± 2.36% follow-up) compared to the control group (3.16 ± 0.78 baseline, 4.04 ± 1.28% follow-up) (P < 0.05). Retrograde shear in the LV-HIIT group decreased significantly (P < 0.05), and no significant decrease in retrograde shear was seen in the CMIT group. Anterograde shear after LV-HIIT increased significantly (P < 0.05) but was unchanged in the CMIT group. However, oscillatory shear index in both exercise groups decreased significantly (P = 0.029). Nitrite/nitrate (NOx) level increased in both exercise groups, but the increase was greater in the LV-HIIT group (P < 0.001). The results indicate that by increasing NOx, HIIT decreases the oscillatory shear-induced improvement in FMD and outward artery remodelling in patients with type 2 diabetes.

show abstract

“…6.1 ± 1.8) in patients with T2D. In another study, Madsen et al. (2015) showed that after low‐volume HIIT, FMD increased more in healthy persons (41%) than in patients with T2D (23%).…”

Section: Discussionmentioning

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Improved brachial artery shear patterns and increased flow‐mediated dilatation after low‐volume high‐intensity interval training in type 2 diabetes

Afousi

Izadi

Rakhshan

et al. 2018

Experimental Physiology

View full text Add to dashboard Cite

show abstract

“…High intensity interval training (HIIT) has been proposed to be a time-efficient (low volume) method to improve aspects related to body composition and disease (Madsen et al, 2015a; Madsen et al, 2015b; Sijie et al, 2012; Talanian et al, 2007). Madsen et al (2015a) showed only a modest improvement in anti-inflammatory cytokine after eight weeks of HIIT for subjects at risk for metabolic syndrome individuals, while inflammatory cytokines did not change.…”

Section: Introductionmentioning

confidence: 99%

Impact of long-term high-intensity interval and moderate-intensity continuous training on subclinical inflammation in overweight/obese adults

et al. 2016

View full text Add to dashboard Cite

Obesity is a risk factor able to trigger several inflammatory alterations and the imbalance between pro- and anti-inflammatory cytokine productions. Physical exercise is an important strategy for reduction of inflammatory established process. The aim of this study was to evaluate the effect of 16 weeks of three exercise training programs in the inflammatory profile and insulin resistance in overweight/obesity. Thirty two men and women (46.4±10.1 years; 162.0±9.1 cm; 82.0±13.6 kg) were divided into three groups for training on a treadmill: continuous at 70% maximum heart rate (HRmax) 5 times a week (CONT); 1×4 min (1-bout) and 4×4 min (high intensity interval training, HIIT) at 90% HRmax 3 times a week. Interleukin (IL) 6 and IL-10, tumor necrosis factor-alpha (TNF-α), insulin and adiponectin levels were analyzed by enzyme-linked immunosorbent assay, and homeostasis model assessment insulin resistance was calculated. After 16 weeks of training blood concentrations of IL-6 decreased in the HIIT group (P=0.035), TNF-α decreased in the CONT (P=0.037) and increased in HIIT (P=0.001) and adiponectin decreased in the three training models. There was a trend towards decreased body weight and body mass index (BMI) after HIIT only (P=0.059 and P=0.060, respectively). Despite the decrease of adiponectin and the increase of TNF-α in HIIT group, insulin sensitivity showed a trend for improvement (P=0.08). HIIT program decreased IL-6 at rest and although not significant was the only who tended to decrease total body weight and BMI. Taken together, our data suggest that both HIIT as well as CONT exercises training program promotes changes in inflammatory profile in overweight/obesity, but dissimilar response is seen in TNF-α levels.

show abstract

“…Meta-analyses have demonstrated that, compared to aerobic exercise, HIT is more effective at improving insulin resistance (Jelleyman et al, 2015) and V O2max (Milanovic et al, 2015) in healthy sedentary individuals. In T2D patients, HIT has been shown to be associated with improvements in insulin sensitivity (Karstoft et al, 2014), glycaemic control (Little et al, 2011), and endothelial function (Madsen et al, 2015). However, due to the required recovery periods in between high-intensity bouts, most available HIT protocols are not as time-efficient as often claimed (Gillen & Gibala, 2014), and even in submaximal HIT protocols the high number of high-intensity bouts per training session results in high perceived exertion (Little et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

A comparison of the health benefits of reduced-exertion high-intensity interval training (REHIT) and moderate-intensity walking in type 2 diabetes patients

Ruffino

Songsorn

Haggett

et al. 2017

Appl. Physiol. Nutr. Metab.

View full text Add to dashboard Cite

show abstract

Functional and structural vascular adaptations following 8 weeks of low volume high intensity interval training in lower leg of type 2 diabetes patients and individuals at high risk of metabolic syndrome

Abstract: HIIT induced an improvement of endothelium-dependent FMD and significant outwards artery modelling. No changes in circulating cell adhesion molecules were observed.

Cited by 31 publications

References 52 publications

Improved brachial artery shear patterns and increased flow‐mediated dilatation after low‐volume high‐intensity interval training in type 2 diabetes

Improved brachial artery shear patterns and increased flow‐mediated dilatation after low‐volume high‐intensity interval training in type 2 diabetes

Impact of long-term high-intensity interval and moderate-intensity continuous training on subclinical inflammation in overweight/obese adults

A comparison of the health benefits of reduced-exertion high-intensity interval training (REHIT) and moderate-intensity walking in type 2 diabetes patients

Contact Info

Product

Resources

About