Functional Architecture of Executive Control and Associated Event-Related Potentials

Abstract

Medial frontal cortex enables executive control by signaling conflict, monitoring and predicting events and outcomes, and goal maintenance, indexed by event-related potentials (ERP). In monkeys performing a saccade countermanding (stop-signal) task, we recorded EEG over and neural spiking across all layers of the supplementary eye field (SEF). Neurons did not contribute to reactive response inhibition. Those signaling response conflict and tracking and predicting the timing of events for successful stopping had different spike widths and were concentrated differently across layers. Conflict neurons were in all layers and those encoding temporal parameters were concentrated in L2/3 and L5. The N2 indexed reward association with variation of polarization predicted by conflict and event timing neurons in L2/3 but not L5/6. The P3 indexed the timing of the upcoming event with variation of polarization predicted by event timing neurons in L2/3 but not L5/6. These findings reveal novel features of the cortical microcircuitry supporting executive control and producing associated ERP.