Functional Assessment of Coronary Artery Disease by Myocardial Flow Reserve Versus Pressure-wire Based Assessment

Abstract

Positron emission tomography (PET) permits the noninvasive quantification of myocardial blood flow (MBF). Myocardial flow reserve (MFR), calculated by dividing stress MBF by rest MBF is a reliable index for the functional information of coronary artery disease.A pressure-derived physiological index, such as fractional flow reserve (FFR) is also an important measurement. Both MFR and FFR values are used to evaluate coronary physiology; however, but they are not interchangeable because each test has certain discrepancies. In this systematic review, we provide an overview of coronary physiology with PET compared to pressurederived physiological indices.

18F FDG PET Cardiac Imaging for Myocardial Viability Assessment in NINMAS

“…Prognosis does not improve with revascularization in cases of functionally insignificant coronary artery stenosis rather is excessively costly and potentially harmful due to the considerable risk of periprocedural myocardial infarction or subacute stent thrombosis, even with the use of drug-eluting stents (1). In this regard, Myocardial Perfusion Imaging (MPI) is a well-established and important tool which is indicated for risk stratification, detection, evaluation and prognosis of coronary artery disease (CAD) (2,3). Stress-rest single photon emission computed tomography (SPECT) gated MPI is performed to determine myocardial ischemia and/or myocardial infarction as well as left ventricular function.…”