Functional Assessment of Quality of Life Using EORTC QLQ-CR29 in Patients with Colon Cancer at King Abdulaziz University Hospital

AlOtaibi, Ssakher M; AlAbbas, Faisal; Bashnini, Nada K

doi:10.4172/2329-6771.1000151

Cited by 5 publications

(6 citation statements)

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“…Patients with neoplastic diseases were administered the QLQ‐C30 and the QLQ‐CR29 modules of the European Organization for Research and Treatment of Cancer (EORTC). Patients with both inflammatory/ischaemic and neoplastic diseases were administered the Gastrointestinal Quality of Life Index (GIQLI) questionnaire . The latter investigates the following gastrointestinal‐related items or domains: abdominal pain, bloating, bowel frequency, bowel urgency, diarrhoea, constipation and nausea.…”

Section: Methodsmentioning

confidence: 99%

“…The GIQLI questionnaire was administered before surgery and 2 and 6 weeks after surgery, in strict accordance with the instructions for the GIQLI questionnaire; if a symptom or dysfunction was present, patients were asked to indicate its importance in influencing their quality of life on a five‐point scale (0 = all of the time; 1 = most of the time; 2 = sometimes; 3 = occasionally; 4 = never). The EORTC QLC‐C30 and the EORTC QLC‐CR29 questionnaires were administered before surgery and 3 and 6 months after surgery; each item had to be assigned a score ranging from 1 (not at all) to 4 (very much) .…”

Section: Methodsmentioning

confidence: 99%

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Ileocaecal valve syndrome after surgery in adult patients: myth or reality?

et al. 2017

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Ileocaecal valve syndrome after surgery in adult patients: myth or reality?

et al. 2017

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“…Work-life and productivity, interpersonal relationships and other social activities can be impacted by treatment [ 14 ] and ostomy surgery [ 11 , 12 ]. For example, it is common for patients to present a worsening of physical function, cognitive, role and social function and symptoms of pain, nausea and vomiting and constipation due to chemotherapy.…”

Section: Introductionmentioning

confidence: 99%

“…However, very few of these were prospective studies [ 6 , 12 , 17 , 18 ]. Most were case-control [ 13 , 19 , 20 ] or cross-sectional [ 14 , 21 , 22 ] in design or compared patients with and without ostomies [ 5 , 6 , 10 – 12 , 23 – 25 ]. Some evaluated different reasons for ostomies [ 26 ], or considered colostomy and ileostomy together [ 8 , 17 ].…”

Section: Introductionmentioning

confidence: 99%

Time after ostomy surgery and type of treatment are associated with quality of life changes in colorectal cancer patients with colostomy

et al. 2020

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Purpose Quality of life in colorectal cancer patients may be affected by colostomy and treatment, but relevant studies are still scarce and contradictory. The present study aimed to evaluate the association between colostomy time and treatment type with quality of life in colorectal cancer patients. Methods A prospective observational study of 41 patients with colorectal cancer was conducted on three occasions T0, T1 and T2 (0–2; 3–5 and 6–8 months after ostomy surgery, respectively). The treatments prescribed were: surgery alone, chemotherapy or radiotherapy, or chemoradiotherapy. European Organization for Research and Treatment of Cancer questionnaires were used to evaluate quality of life. Worsening clinical changes were evaluated considering difference in scores between times of surgery ≥±9 points. Results Regarding ostomy surgery, scores in physical function improved between T0 and T1 and these better scores were maintained at T1 to T2. The same was observed for urinary frequency, appetite loss and dry mouth. Chemoradiotherapy was associated with worse scores for global health status, nausea and vomiting, bloating and dry mouth. Although significant differences were not observed in some domains in the Generalized Estimating Equations analysis, patients showed noticeable changes for the worse in the pain, anxiety, weight concern, flatulence and embarrassment domains during these periods. Conclusions Colostomy improved quality of life at 3–5 months in most domains of quality of life and remained better at 6–8 months after surgery. Chemoradiotherapy had a late negative influence on quality of life. Health teams could use these results to reassure patients that this procedure will improve their quality of life in many functional and symptomatic aspects.

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“…Bowel function and quality of life before and after surgery were investigated by means of two validated questionnaires: the Gastrointestinal Quality of Life (GIQLI) questionnaire, which was administered to all patients with inflammatory, ischemic, or neoplastic disease, and the European Organization for Research and Treatment of Cancer (EORTC) QLQ-CR29 modules, which were selectively administered only to patients with neoplastic disease [12][13][14]. The GIQLI questionnaire was filled out by patients at the time of surgery, 2 weeks after surgery, and 6 weeks after surgery, evaluating the following selected items: abdominal pain, bloating, bowel frequency, bowel urgency, bowel movement, diarrhea, constipation, and nausea (i.e., question numbers 1, 3,7,30,31,32,33,36).…”

Section: Methodsmentioning

confidence: 99%

Ileocecal valve syndrome and vitamin b12 deficiency after surgery: a multicentric prospective study

et al. 2020

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Patients undergoing colon resection are often concerned about their functional outcomes after surgery. The primary aim of this prospective, multicentric study was to assess the intestinal activity and health-related quality-of-life (HRQL) after ileocecal valve removal. The secondary aim was to evaluate any vitamin B12 deficiency. The study included patients undergoing right colectomy, extended right colectomy and ileocecal resection for either neoplastic or benign disease. Selected items of GIQLI and EORTC QLQ-CR29 questionnaires were used to investigate intestinal activity and HRQL before and after surgery. Blood samples for vitamin B12 level were collected before and during the follow-up period. The empirical rule effect size (ERES) method was used to explain the clinical effect of statistical results. Linear mixed effect (LME) model for longitudinal data was applied to detect the most important parameters affecting the total score. A total of 158 patients were considered. Applying the ERES method, the analysis of both questionnaires showed clinically and statistically significant improvement of HRQL at the end of the follow-up period. Applying the LME model, worsening of HRQL was correlated with female gender and ileum length when using GIQLI questionnaire, and with female gender, open approach, and advanced cancer stage when using the EORTC QLQ-CR29 questionnaire. No significant deficiency in vitamin B12 levels was observed regardless of the length of surgical specimen. In our series, no deterioration of HRQL and no vitamin B12 deficiency were found during the follow-up period. Nevertheless, warning patients about potential changes in bowel habits is mandatory. In our series, no deterioration of HRQL and no vitamin B12 deficiency were found during the follow-up period. Nevertheless, warning patients about potential changes in bowel habits is mandatory.

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Functional Assessment of Quality of Life Using EORTC QLQ-CR29 in Patients with Colon Cancer at King Abdulaziz University Hospital

Cited by 5 publications

References 0 publications

Ileocaecal valve syndrome after surgery in adult patients: myth or reality?

Ileocaecal valve syndrome after surgery in adult patients: myth or reality?

Time after ostomy surgery and type of treatment are associated with quality of life changes in colorectal cancer patients with colostomy

Ileocecal valve syndrome and vitamin b12 deficiency after surgery: a multicentric prospective study

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