Demands for new architecture that is more fluid, interactive, functional, and adaptable to the changes of economic atmosphere and design principles are changing the concept of forms and aesthetics. However, despite the role of technology, the architectural design elements of buildings have often been developed separately, in terms of artistic and functional features, in a way that affects the flexibility and quality of the design process along with its impact on the built environment. This issue calls for the need to explore an interdisciplinary design approach that combines biology and architecture in order to improve both individual and overall quality of design. This paper will, therefore, provide a review of literature that draws on the important characteristics of bio-inspired design material and its impact on an effective design in a way that can capture the specifications needed to enhance the development of a digital prototype that caters for the flexibility and overall quality of design aesthetically and functionally.