Functional biomedical materials derived from proteins in the acquired salivary pellicle

Zhang, Fan; Cheng, Ziying; Ding, Chunmei; Li, Jianshu

doi:10.1039/d1tb01121a

Cited by 6 publications

(10 citation statements)

References 180 publications

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“…Surface coating or modification, which preserves the original properties of the material and changes only the surface properties, has been recognized as a promising strategy for introducing antibacterial efficacy into biomaterials. Some bionic surface morphologies with high aspect ratios are effective against colonization by bacteria, although the mechanism of antibacterial activity is not clear [3][4][5][6][7][8]. For methods of tailoring surface chemistry, substrates can be chemically modified or physically coated with a variety of antibacterial substances, including polymers, functional groups, inorganic nanoparticles, hydrogels, and antibiotics [9].…”

Section: Introductionmentioning

confidence: 99%

Antibacterial-Based Hydrogel Coatings and Their Application in the Biomedical Field—A Review

Peng

Shi

Chen

et al. 2023

JFB

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Hydrogels exhibit excellent moldability, biodegradability, biocompatibility, and extracellular matrix-like properties, which make them widely used in biomedical fields. Because of their unique three-dimensional crosslinked hydrophilic networks, hydrogels can encapsulate various materials, such as small molecules, polymers, and particles; this has become a hot research topic in the antibacterial field. The surface modification of biomaterials by using antibacterial hydrogels as coatings contributes to the biomaterial activity and offers wide prospects for development. A variety of surface chemical strategies have been developed to bind hydrogels to the substrate surface stably. We first introduce the preparation method for antibacterial coatings in this review, which includes surface-initiated graft crosslinking polymerization, anchoring the hydrogel coating to the substrate surface, and the LbL self-assembly technique to coat crosslinked hydrogels. Then, we summarize the applications of hydrogel coating in the biomedical antibacterial field. Hydrogel itself has certain antibacterial properties, but the antibacterial effect is not sufficient. In recent research, in order to optimize its antibacterial performance, the following three antibacterial strategies are mainly adopted: bacterial repellent and inhibition, contact surface killing of bacteria, and release of antibacterial agents. We systematically introduce the antibacterial mechanism of each strategy. The review aims to provide reference for the further development and application of hydrogel coatings.

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Section: Introductionmentioning

confidence: 99%

Antibacterial-Based Hydrogel Coatings and Their Application in the Biomedical Field—A Review

Peng

Shi

Chen

et al. 2023

JFB

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“…Intriguingly, even at extremely low concentrations, proteins can assemble at interfaces/surfaces and manipulate biological activities, exhibiting distinctive behaviors. The formation of a thin protein coating can enable cells or organs to undertake various physiological roles, ranging from acting as a lubricating layer in human joints and teeth, 12 to serving as adhesive proteins for cell attachment, 13 or as chorion proteins shielding eggs from pathogens. 14 On the other hand, protein adsorption in the bloodstream is a key factor for thrombosis.…”

Section: Interfacial Behaviors Of Functional Proteins In Organismsmentioning

confidence: 99%

“…65 Mucins and other saliva proteins are adsorbed on teeth. Then, the thin, proteinaceous layer that forms on the tooth surface is termed an “acquired salivary pellicle.” 12 The pellicle layer diminishes friction among opposing teeth as well as between teeth and mucosal surfaces. Remarkably, the introduction of salivary pellicles between solid surfaces leads to a reduction in the friction coefficient of up to 20.…”

Section: Interfacial Behaviors Of Functional Proteins In Organismsmentioning

confidence: 99%

“…This layer originates predominantly from salivary proteins but also incorporates proteins from gingival crevicular fluid and oral microbes. 12 The formation of a salivary pellicle is a highly selective process involving specific interactions between tooth HAp and certain salivary proteins. This process, in general, proceeds in two stages: the initial swift protein adsorption (within minutes of saliva exposure) followed by a slower phase of protein accumulation (over several hours) (Fig.…”

Section: Interfacial Behaviors Of Functional Proteins In Organismsmentioning

confidence: 99%

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Protein-based bioactive coatings: from nanoarchitectonics to applications

Fu,

Wang,

Zhou

et al. 2024

Chem. Soc. Rev.

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“…and immunoglobulins. 8,9 Only specific proteins within the saliva are found in the initial enamel cuticle, including statherine, histatin, and proline-rich proteins. 10,11 Because of the semipermeable character of its membrane, the pellicle protects the tooth surface from excessive losses of calcium and phosphate and thus from acid influences.…”

mentioning

confidence: 99%

Functionalization of a zirconia surface by covalently immobilized fibronectin and its effects on resistance to thermal, acid, and mechanical exposure

Palkowitz,

Tuna,

Kaufmann

et al. 2024

J Biomed Mater Res

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Silane chemistry has emerged as a powerful tool for surface modification, offering a versatile means to enhance the properties of various substrates, such as dental implant abutment materials. In this study, we investigated the stability of the 3‐aminopropyldiisopropylethoxysilane (APDS) layer on yttria‐partially stabilized zirconia (Y‐TZP) surfaces after mechanical, acid, and thermal treatment in order to simulate fluctuations within the oral cavity. To accomplish that, the viability of human gingival fibroblasts on APDS‐modified surfaces after applied treatment strategies was assessed by live/dead staining. Moreover, the hydrolysis stability and enzymatic degradation resistance of crosslinked fibronectin to the APDS layer was examined by immunostaining and western blot. The results revealed that the applied modifications were not affected by the different treatment conditions and could withstand the fluctuations in the oral cavity. Furthermore, crosslinked fibronectin on silanized Y‐TZP was stable against hydrolysis over 21 days and enzymatic degradation. We thus can conclude that the proposed functionalization method has high potential to tolerate harmful effects within the oral cavity and remains unchanged on the surface.

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Functional biomedical materials derived from proteins in the acquired salivary pellicle

Abstract: In the oral environment, the acquired salivary pellicle (ASP) on the tooth surface comprises proteins, glycoproteins, carbohydrates, and lipids. The ASP can specifically and rapidly adsorb on the enamel surface...

Cited by 6 publications

References 180 publications

Antibacterial-Based Hydrogel Coatings and Their Application in the Biomedical Field—A Review

Antibacterial-Based Hydrogel Coatings and Their Application in the Biomedical Field—A Review

Protein-based bioactive coatings: from nanoarchitectonics to applications

Functionalization of a zirconia surface by covalently immobilized fibronectin and its effects on resistance to thermal, acid, and mechanical exposure

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