Functional bioprobe for responsive imaging and inhibition of amyloid-β oligomer based on curcuminoid scaffold

Recent Advances in the Development of Near-Infrared Fluorescent Probes for the in Vivo Brain Imaging of Amyloid-β Species in Alzheimer’s Disease

“…JP-1 produced impressive and responsive emission up to 5-folds in specific response upon binding to Aβ oligomers. The in vitro results suggested the binding of JP-1 with Aβ oligomer and were correlated with obtained in vivo images of Aβ deposits in the early aged (5 months) Tg mice models …”

“…48 Recently, the structural modification in the CRANAD-58 was engineered to develop "off-on" NIRF probes (Probe-9) with better in vitro and in vivo performances by Liu et al correlated with obtained in vivo images of Aβ deposits in the early aged (5 months) Tg mice models. 33 ■ QUINOXALINONE AND QUINOLINE DERIVATIVES…”

Small Molecular Fluorescent Probes for Alzheimer's Disease Associated Active Species

“…Pan group designed and synthesized two “D‐A‐D” conjugated fluorescent probes 21 a and 21 b (Figure 5) for selective imaging and inhibition of Aβ oligomer [63] . Structurally speaking, these probes composed of N, N‐dimethylamine or N, N‐dimethylaniline as the donor, pyrimidine moiety as the acceptor group, which could generate turn‐on fluorescence response after interaction with Aβ protein through π‐π interaction and hydrogen bond effect.…”

“…Among them, probes 20 a, 20 b and 20 c ( Pan group designed and synthesized two "D-A-D" conjugated fluorescent probes 21 a and 21 b (Figure 5) for selective imaging and inhibition of Aβ oligomer. [63] Structurally speaking, these probes composed of N, N-dimethylamine or N, N-dimethylaniline as the donor, pyrimidine moiety as the acceptor group, which could generate turn-on fluorescence response after Chemistry-A European Journal interaction with Aβ protein through π-π interaction and hydrogen bond effect. Further experiments demonstrated that these probes could solely target Aβ oligomer in brain slices and brain tissue of AD mice.…”

Recent advances in small molecular near-infrared fluorescence probes for a targeted diagnosis of the Alzheimer disease

“…[136][137][138][139] It was envisioned that NIR-II AD probes would offer high diagnosis quality than by traditional visible and NIR-I fluorescence AD probes. [140][141][142][143][144][145] Furthermore, it is well evidenced that the donor-acceptor-donor (D-A-D) structured probes have relatively low bandgap, and absorbance and emis- sion in the long wavelength region, which are appealing for AD sensing in vivo. 146,147 Motivated by this prospect, Zhao and coworkers reported a new "D-A-D" NIR-II biosensor utilized for AD imaging, named Eth-BF (Fig.…”