We study existence, uniqueness and regularity of solutions for ordinary differential equations with infinitely many derivatives such as (linearized versions of) nonlocal field equations of motion appearing in particle physics, nonlocal cosmology and string theory. We develop an appropriate Lorentzian functional calculus via Laplace transform which allows us to interpret rigorously an operator of the form f (∂ t ) on the half line, in which f is an analytic function. We find the most general solution to the equationin the space of exponentially bounded functions, and we also analyze in full detail the delicate issue of the initial value problem. In particular, we state conditions under which the solution φ admits a finite number of derivatives, and we prove rigorously that if an a priori data directly connected with our Lorentzian calculus is specified, then the initial value problem is well-posed and it requires only a finite number of initial conditions. *