Functional Carboxymethylcellulose/Zein Bionanocomposite Films Based on Neomycin Supported on Sepiolite or Montmorillonite Clays

Abstract

The present work introduces new functional bionanocomposite materials based on layered montmorillonite and fibrous sepiolite clays and two biopolymers (carboxymethylcellulose polysaccharide and zein protein) to produce drug-loaded bionanocomposite films for antibiotic topical delivery. Neomycin, an antibiotic indicated for wound infections, was employed as the model drug in this study. The physical properties and the antimicrobial activity of these materials were evaluated as a function of the type of hybrid and the amount of zein protein incorporated in the bionanocomposite films. In addition, the interfacial and physicochemical properties of these new clay–drug hybrids have been studied through a combination of experimental and computational methodologies, where the computational studies confirm the intercalation of neomycin into the montmorillonite layers and the possible penetration of the drug in the tunnels of sepiolite, as pointed out by N 2 adsorption and X-ray diffraction techniques. The antimicrobial activity of these bionanocomposite materials show that the films based on montmorillonite–neomycin display a more pronounced inhibitory effect of the bacterial growth than those prepared with the sepiolite–neomycin hybrid. Such effect can be related to the difficult release of neomycin adsorbed on sepiolite due to a strong interaction between both components.

Gentamicin-Montmorillonite Intercalation Compounds as an Active Component of Hydroxypropylmethylcellulose Bionanocomposite Films with Antimicrobial Properties

“…Consequently, the amount of antibiotic or antimicrobial agents required to achieve a satisfactory effect could decrease significantly. In fact, some recent works have addressed the use of clay-based systems in combination with biopolymers to produce effective bionanocomposites with a biocide effect (Aguzzi et al, 2014;Ambrogi et al, 2017;Rebitski et al, 2018;Lisuzzo et al, 2020). In particular, examples of Gtclay bionanocomposites for uses in implants and scaffolds have been described (e.g.…”

Raw and modified clays and clay minerals for the removal of pharmaceutical products from aqueous solutions: State of the art and future perspectives

“…3 10 3.41 C NA NA 2.5 (Lv, Wu, Li, Liao, & Liu, 2014) Albagel Na-Mt. 80 NA 3.5 C ~7 40 76.0 (Camazano, Sanchez, Vicente, & Dominguez-Gil, 1980) (Rebitski, Alcântara, et al, 2018) (Ghadiri, Hau, Chrzanowski, Agus, & Rohanizadeh, 2013)…”

Halloysite Nanotubes Coated by Chitosan for the Controlled Release of Khellin

“…In recent years, hybrid nanomaterials composed by biopolymers and inorganic nanoparticles have attracted growing interest within several fields, including biomedicine [ 1 , 2 , 3 , 4 , 5 ], pharmaceutics [ 6 , 7 , 8 , 9 , 10 ], food packaging [ 11 , 12 , 13 , 14 , 15 ], remediation [ 16 , 17 ] and cultural heritage [ 18 , 19 , 20 ]. As evidenced in a recent review [ 21 ], both ionic and non-ionic polysaccharides can be suitable polymers for the development of functional nanocomposites, with excellent performances in terms of thermal stability, barrier properties and mechanical behavior.…”