2024
DOI: 10.1038/s41398-024-02956-2
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Functional changes in sleep-related arousal after ketamine administration in individuals with treatment-resistant depression

Elizabeth D. Ballard,
Deanna Greenstein,
Philip T. Reiss
et al.

Abstract: The glutamatergic modulator ketamine is associated with changes in sleep, depression, and suicidal ideation (SI). This study sought to evaluate differences in arousal-related sleep metrics between 36 individuals with treatment-resistant major depression (TRD) and 25 healthy volunteers (HVs). It also sought to determine whether ketamine normalizes arousal in individuals with TRD and whether ketamine’s effects on arousal mediate its antidepressant and anti-SI effects. This was a secondary analysis of a biomarker… Show more

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