Functional characterisation of the Drosophila cg6568 gene in host defence against Mycobacterium marinum

Jin, Hyo Sun; Lee, Hyemi; Lee, Da-Hye; Cha, Guang-Ho; Cho, Kyoung Sang; Jang, Jichan; Jo, Eun-Kyeong

doi:10.1016/j.micinf.2017.02.001

Cited by 1 publication

(3 citation statements)

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“…Equally, at this level, the interaction with the epithelial cells once the macrophage is destroyed by the growth of the bacilli should be still clarified [13]. In this regard, Drosophila melanogaster appears to be a good model to clarify the interaction of the bacilli with the respiratory and intestinal epithelia [14]. A new recent model built in Netlogo platform has linked the lack of drainage in the alveoli of the upper lobes with the local accumulation of bacilli.…”

Section: The Interaction At the Alveoli (2)mentioning

confidence: 99%

“…In both lesions there is a constant drainage of dormant bacilli carried by foamy macrophages towards the bronchial tree (11) which majoritarily are drained towards the gastrointestinal tract (12) but can reenter the lung parenchyma again (1). Systemic reinfection can be done through an over infected lymph node, which drains towards the right heart and it is pumped again into the lung (13), or directly from the lesions, reaching the left heart and being able to induce extrapulmonary lesions (14). * See Figure 1 for details: 1.…”

Section: Figure 1 Fourteen Steps To Frame Mycobacterium Tuberculosis Immune-modellingmentioning

confidence: 99%

“…Drainage towards the gastrointestinal tract; 13&14. Systemic reinfection through an over infected lymph node (13) or directly from the lesions (14).…”

Section: Figure 1 Fourteen Steps To Frame Mycobacterium Tuberculosis Immune-modellingmentioning

confidence: 99%

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Can systems immunology lead tuberculosis eradication?

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et al. 2018

Current Opinion in Systems Biology

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25 years after the declaration of a Global Emergency by the World Health Organization, tuberculosis (TB) remains a major enemy to the humankind. During this period, much progress has been done to better understand its natural history, revealing its huge complexity, which highlighted the need for implementing systems immunology approaches. Recent advances focused in understanding the role of macrophage subtypes and dendritic cells role, the importance of cytokine balance, and the antigenic repertoire. Identification of early irruption of polymorphonuclear neutrophils and extracellular growth of the bacilli seem to be the most disruptive factors to understand the evolution towards active TB. Their inclusion in future models will provide new tools for the better understanding of the tuberculosis.

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Section: The Interaction At the Alveoli (2)mentioning

confidence: 99%