Functional characterization and substrate promiscuity of sesquiterpene synthases from Tripterygium wilfordii

Tong, Yuru; Hu, Tianyuan; Tu, Lichan; Chen, Kang; Tie-zheng, Liu; Su, Ping; Song, Yadi; Liu, Yuan; Huang, Luqi; Gao, Wei

doi:10.1016/j.ijbiomac.2021.07.004

Cited by 6 publications

(2 citation statements)

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“…Phylogenetically clustering with bacterial and fungal TPSs, linalool synthase has a distinct sequence organization and functional motifs that are absent in plant TPSs, suggesting its microbial origin, and potentially obtained by plants through horizontal gene transfer. 131 Many of the linalool-producing plants, such as Tripterygium wilfordii and Ficus carica , possess two functional linalool synthases, 132,133 and several plants have three mTPSs that are capable of synthesizing linalool, e.g. , tomato and citrus, implicating potential duplication and neofunctionalization process of linalool synthase.…”

Section: Language Evolution—biosynthesis Of Plant Signaling Metabolitesmentioning

confidence: 99%

Functions and biosynthesis of plant signaling metabolites mediating plant–microbe interactions

Huang

2022

Nat. Prod. Rep.

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Section: Language Evolution—biosynthesis Of Plant Signaling Metabolitesmentioning

confidence: 99%

Functions and biosynthesis of plant signaling metabolites mediating plant–microbe interactions

Huang

2022

Nat. Prod. Rep.

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“…The biosynthesis begins with the generation of the C5 skeletal units, isopentenyl diphosphate (IPP) and 3,3-dimethylallyl diphosphate (DMAPP). Despite the structural diversity of terpenoids, their biosynthesis consistently initiates with IPP and DMAPP, both of which are generated in nature via two main pathways: the methylerythritol phosphate (MEP) pathway and the mevalonate (MVA) pathway, representing the initial stages of terpenoid synthesis (Chen et al 2021b ; Tong et al 2021 ). The MVA pathway is primarily found in eukaryotes, including yeast, higher plants and animals, and some archaea.…”

Section: Introductionmentioning

confidence: 99%

The microbial biosynthesis of noncanonical terpenoids

Ma,

Li,

et al. 2024

Appl Microbiol Biotechnol

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Terpenoids are a class of structurally complex, naturally occurring compounds found predominantly in plant, animal, and microorganism secondary metabolites. Classical terpenoids typically have carbon atoms in multiples of five and follow well-defined carbon skeletons, whereas noncanonical terpenoids deviate from these patterns. These noncanonical terpenoids often result from the methyltransferase-catalyzed methylation modification of substrate units, leading to irregular carbon skeletons. In this comprehensive review, various activities and applications of these noncanonical terpenes have been summarized. Importantly, the review delves into the biosynthetic pathways of noncanonical terpenes, including those with C6, C7, C11, C12, and C16 carbon skeletons, in bacteria and fungi host. It also covers noncanonical triterpenes synthesized from non-squalene substrates and nortriterpenes in Ganoderma lucidum, providing detailed examples to elucidate the intricate biosynthetic processes involved. Finally, the review outlines the potential future applications of noncanonical terpenoids. In conclusion, the insights gathered from this review provide a reference for understanding the biosynthesis of these noncanonical terpenes and pave the way for the discovery of additional unique and novel noncanonical terpenes. Key points •The activities and applications of noncanonical terpenoids are introduced. •The noncanonical terpenoids with irregular carbon skeletons are presented. •The microbial biosynthesis of noncanonical terpenoids is summarized.

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Screening and modification of (+)-germacrene A synthase for the production of the anti-tumor drug (−)-β-elemene in engineered Saccharomyces cerevisiae

Hu,

Zhang,

Bai

et al. 2024

International Journal of Biological Macromolecules

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Functional characterization and substrate promiscuity of sesquiterpene synthases from Tripterygium wilfordii

Cited by 6 publications

References 58 publications

Functions and biosynthesis of plant signaling metabolites mediating plant–microbe interactions

Functions and biosynthesis of plant signaling metabolites mediating plant–microbe interactions

The microbial biosynthesis of noncanonical terpenoids

Screening and modification of (+)-germacrene A synthase for the production of the anti-tumor drug (−)-β-elemene in engineered Saccharomyces cerevisiae

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