Functional Characterization of Cucumis metuliferus Proteinase Inhibitor Gene (CmSPI) in Potyviruses Resistance

Lin, Chia-Wei; Su, Mei-Hsiu; Lin, Yang; Chung, Chien-Hung; Ku, Hsin-Mei

doi:10.3390/v7072799

Cited by 6 publications

(2 citation statements)

References 42 publications

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“…An antiviral study of horned melon alkaloids extracted from the pulp (concentrations of 6.25 and 200 mg/mL) was successfully conducted for Hepatitis B and Bursal disease virus using fibroblast cells of embryonated chickens and albino rats [44,45]. There are also some indications that horned melon has resistance against many pathogenic viruses because of specific genes encoded in proteinase inhibitors [46].…”

Section: Antiviral Activitymentioning

confidence: 99%

Horned Melon (Cucumis metuliferus E. Meyer Ex. Naudin)—Current Knowledge on Its Phytochemicals, Biological Benefits, and Potential Applications

et al. 2022

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Recent studies reveal that numerous non-edible parts of fruits and vegetables, as well as food wastes, are a good source of phytochemicals that can be extracted and reintroduced into the food chain as natural food additives. Horned melon or kiwano (Cucumis metuliferus E. Mey. Ex. Naudin) is a fruit rich in various phytochemical components important in the daily diet. After primary processing, horned melon non-edible parts (e.g., peels and seeds) can represent raw materials that can be utilized in numerous applications. Among under-researched fruits, this study aims to present the potential of using horned melon edible and non-edible parts based on current knowledge on nutritional value, phytochemicals, biological activity, as well as biological benefits. Overall, this review concluded that the biological properties of horned melon are associated with the phytochemicals present in this fruit and its waste parts. Further studies should be conducted to identify phytochemicals and valorize all horned melon parts, assess their biological efficacy, and promote their potential uses in different health purposes.

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Section: Antiviral Activitymentioning

confidence: 99%

Horned Melon (Cucumis metuliferus E. Meyer Ex. Naudin)—Current Knowledge on Its Phytochemicals, Biological Benefits, and Potential Applications

et al. 2022

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“…From a plant defense perspective, kiwano is also reported to have resistance against many pathogens, including viruses. It was found that resistant C. metuliferus lines have genes that encode proteinase inhibitors that are responsible for virus resistance [63].…”

Section: Antiviral Propertiesmentioning

confidence: 99%

Bioactive Compounds of Horned Melon (Cucumis Metuliferus E. Meyer ex Naudin)

Vieira¹,

Grosso²,

Rodrigues³

et al. 2020

Reference Series in Phytochemistry

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Kiwano (Cucumis metuliferus E. Meyer ex Naudin) is a neglected crop from the Cucurbitaceae family with recognized nutritional and medicinal properties, especially in African countries. This review describes the recent findings regarding the nutritional and phytochemical composition of kiwano, supporting the pharmacological properties of this versatile fruit and identifying opportunities for further research. Also, the potential economic valorization of kiwano is discussed, namely, as a source of bioactive compounds for functional food and nutraceutical applications, as well as for the active food packaging sector to extend the shelflife of packaged food. Overall, this chapter concluded that the nutritional value and functional properties, such as anticardiovascular, antidiabetic, antiulcer, antioxidant, anti-inflammatory, antimalarial, and antiviral properties associated to this crop, suggest its potential medicinal and pharmaceutical uses. Further studies should be conducted to isolate and identify the individual chemical constituents of kiwano and assess their biological efficacy. Also, the valorization of the underutilized kiwano parts (leaves, flowers, and roots) should be promoted in terms of health and waste management purposes.

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