Functional characterization of prostaglandin F<sub>2α</sub> receptor in the spinal cord for tactile pain (allodynia)

Muratani, Tadatoshi; Nishizawa, Mikio; Matsumura, Shinji; Mabuchi, Tamaki; Abe, Kohji; Shimamoto, Keiko; Minami, Toshiaki; Ito, Seiji

doi:10.1046/j.1471-4159.2003.01840.x

Cited by 24 publications

(19 citation statements)

References 34 publications

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“…Here morphine did not inhibit the allodynia induced by ACRO-A and ACRO-B (Figure 4b). In agreement with our recent study demonstrating that functional FP-expressing cells that are involved in PGF 2a -induced allodynia exist in the deeper layer of the dorsal horn (Muratani et al, 2003), the increase in [Ca 2 þ ] i by ACRO-A was more prominent in the deeper layer than in the superficial layer in the dorsal horn (Figure 8a and b). It has been known that micromolar concentrations of ACRO-A are generally required to elicit electrophysiological responses and [Ca 2 þ ] i increase in hippocampal and spinal neurons, in marked contrast to the nM dissociation constant in brain and spinal membranes.…”

Section: T Minami Et Alsupporting

confidence: 93%

Acute and late effects on induction of allodynia by acromelic acid, a mushroom poison related structurally to kainic acid

Minami

Matsumura

Nishizawa

et al. 2004

British J Pharmacology

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1 Ingestion of a poisonous mushroom Clitocybe acromelalga is known to cause severe tactile pain (allodynia) in the extremities for a month and acromelic acid (ACRO), a kainate analogue isolated from the mushroom, produces selective damage of interneurons of the rat lower spinal cord when injected either systemically or intrathecally. Since ACRO has two isomers, ACRO-A and ACRO-B, here we examined their acute and late effects on induction of allodynia. 2 Intrathecal administration of ACRO-A and ACRO-B provoked marked allodynia by the first stimulus 5 min after injection, which lasted over the 50-min experimental period. Dose-dependency of the acute effect of ACRO-A on induction of allodynia showed a bell-shaped pattern from 50 ag kg À1 to 0.5 pg kg À1 and the maximum effect was observed at 50 fg kg À1 . On the other hand, ACRO-B induced allodynia in a dose-dependent manner from 50 pg kg À1 to 50 ng kg ). Higher doses of ACRO-A, however, could evoke allodynia dose-dependently from 50 pg kg À1 to 500 ng kg À1 in the ACRO-A-treated mice. The allodynia induced by ACRO-A (500 ng kg À1 ) was not inhibited by Joro spider toxin or NMDA receptor antagonists. These properties of the late allodynia induced by ACRO-A were quite similar to those of the acute allodynia induced by ACRO-B. 5 ACRO-A could increase [Ca 2 þ ] i in the deeper laminae, rather than in the superficial laminae, of the spinal cord. This increase was not blocked by the AMPA-preferring antagonist GYKI52466 and Joro spider toxin. 6 Taken together, these results demonstrate the stereospecificity of ACRO for the induction of allodynia and suggest the presence of a receptor specific to ACRO.

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Section: T Minami Et Alsupporting

confidence: 93%

Acute and late effects on induction of allodynia by acromelic acid, a mushroom poison related structurally to kainic acid

Minami

Matsumura

Nishizawa

et al. 2004

British J Pharmacology

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“…Indeed, FP receptors mediate ␣B-methylene ATP-evoked allodynia (Kunori et al, 2009). These data are supported by the finding that spinal intrathecal administration of PGF 2␣ produces allodynia by activating FP receptors (Muratani et al, 2003).…”

Section: Fp Receptorsmentioning

confidence: 72%

International Union of Basic and Clinical Pharmacology. LXXXIII: Classification of Prostanoid Receptors, Updating 15 Years of Progress

Woodward

Jones

Narumiya³

2011

Pharmacol Rev

395

414

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“…The dorsal horn is a site of a pain transmission, and our result supports other reports on the physiological role of PGF 2 ␣ as a pain modulator ( 1 ). Muratani et al ( 13 ) reported that FPexpressing cells appear in the deeper layer (lamina III and deeper) of the dorsal horn of the spinal cord in conscious mice. Their fi ndings differ slightly from our immunohistochemical data.…”

Section: Discussionmentioning

confidence: 99%

Colocalization of prostaglandin F2α receptor FP and prostaglandin F synthase-I in the spinal cord

Suzuki-Yamamoto

Toida

Sugimoto

et al. 2009

Journal of Lipid Research

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This article is available online at http://www.jlr.org PGF 2 ␣ are controlled by its synthesis and binding site. PGF 2 ␣ is synthesized by PGF synthase (PGFS; EC 1.1.1.188) and binds to a specifi c receptor, FP.PGFS exists as three isozymes: PGFS I (formerly lungtype PGFS), PGFS II (formerly liver-type PGFS) ( 3, 4 ), and prostamide/prostaglandin F synthase ( 5 ). The fi rst two isozymes, PGFS I and PGFS II, belong to the aldo-keto reductase superfamily based on their substrate specifi city, molecular weight ( ‫ف‬ 37 kDa), and amino acid sequences. In arachidonate metabolism, PGFS I and PGFS II catalyze two reductions of PGH 2 to PGF 2 ␣ and PGD 2 to 9 ␣ ,11 ␤ -PGF 2 . PGH 2 is synthesized from arachidonate by cyclooxygenase (COX), and PGD 2 is synthesized from PGH 2 by PGD synthase. The isozymes have different K m values for PGD 2 , i.e., 120 M for PGFS I and 10 M for PGFS II. Prostamide/prostaglandin F synthase was identifi ed recently as a new type of the enzyme that belongs to the thioredoxinlike superfamily ( 5 ). Prostamide/prostaglandin F synthase catalyzes both the reduction of prostamide H 2 to prostamide F 2 ␣ and that of PGH 2 to PGF 2 ␣ . However, PGD 2 does not serve as a substrate for the synthase.PGF 2 ␣ is one of the major prostanoids produced in the rat central nervous system, including the spinal cord ( 6 ), where PGF synthase activity is also detected ( 7 ). We have reported on the existence and localization of PGFS I and PGFS II in the rat spinal cord. Our previous immunocytochemical study of PGFS I in the rat spinal cord showed that the immunoreactivity was distributed widely in the gray substance and was especially strong in neuronal dendrites in laminae I and II of the dorsal horn and in lamina IX of the ventral horn ( 8 ). In contrast, PGFS II was not found in the neuronal elements but was found in ependymal Abstract Prostaglandin F 2 ␣ is synthesized by prostaglandin F synthase, which exists in two types, prostaglandin F synthase I (PGFS I) and prostaglandin F synthase II (PGFS II). Prostaglandin Supplementary key words immunohistochemistry • neuron • dendriteIn the central and peripheral nervous systems, prostaglandin (PG) F 2 ␣ plays unique roles in various physiological and pharmacological activities, such as pain transmission (allodynia) in the spinal cord of conscious mice ( 1 ) and induction of depolarization in the postsynaptic actions of cerebellar Purkinje cell dendrites ( 2 ). These actions of This work was supported in part by the Japan Society for the Promotion of Science, Grants-in-Aid for Encouragement of Young Scientists 16790172 to T.S-Y., for Scientifi c Research 19500295 to K.T., and for Scientifi c Research 18590185 to K.I.; by a grant from the ONO Medical Research Foundation to T.S-Y.; and by a grant from Hayashi Memorial Foundation to T.S-Y.Manuscript received 22 October 2008 and in revised form 13 March 2008 and in re-revised form 30 April 2009. Published, JLR Papers in Press, May 8, 2009 DOI 10.1194 Abbreviations: ABC, avidin-biotin complex; CLSM, confocal la...

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Functional characterization of prostaglandin F_2α receptor in the spinal cord for tactile pain (allodynia)

Abstract: Prostaglandin F 2a (PGF 2a ) binds to its receptor (FP) to increase the intracellular-free calcium concentration ([Ca

Cited by 24 publications

References 34 publications

Acute and late effects on induction of allodynia by acromelic acid, a mushroom poison related structurally to kainic acid

Acute and late effects on induction of allodynia by acromelic acid, a mushroom poison related structurally to kainic acid

International Union of Basic and Clinical Pharmacology. LXXXIII: Classification of Prostanoid Receptors, Updating 15 Years of Progress

Colocalization of prostaglandin F2α receptor FP and prostaglandin F synthase-I in the spinal cord

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Functional characterization of prostaglandin F2α receptor in the spinal cord for tactile pain (allodynia)

Abstract: Prostaglandin F 2a (PGF 2a ) binds to its receptor (FP) to increase the intracellular-free calcium concentration ([Ca

Cited by 24 publications

References 34 publications

Acute and late effects on induction of allodynia by acromelic acid, a mushroom poison related structurally to kainic acid

Acute and late effects on induction of allodynia by acromelic acid, a mushroom poison related structurally to kainic acid

International Union of Basic and Clinical Pharmacology. LXXXIII: Classification of Prostanoid Receptors, Updating 15 Years of Progress

Colocalization of prostaglandin F2α receptor FP and prostaglandin F synthase-I in the spinal cord

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Functional characterization of prostaglandin F_2α receptor in the spinal cord for tactile pain (allodynia)