Functional characterization of STATa/b genes encoding transcription factors from Branchiostoma belcheri

Cao, Yang; Fang, Tony; Fan, Mingli; Wang, Lei; Lv, Caiyun; Song, Xiaojun; Park, Jin; Ma, Fei

doi:10.1016/j.dci.2020.103838

Cited by 6 publications

(3 citation statements)

References 47 publications

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“…During the second phase of WGD, three gene clusters were created: STAT1 and STAT4, STAT2 and STAT6, and STAT3 and STAT5 ( Boudinot et al., 2021 ), Gene loss following duplication occurrences may also restrict the gene growth. The STATs are divided into the STAT-A and STAT-B groups, with STAT1 to STAT4 being a part of STAT-A, and STAT5 and STAT6 being a part of STAT-B ( Cao et al., 2021 ). In the present study, we observed that apart from the absence of stat1b , seven STAT genes have been identified in lumpfish.…”

Section: Discussionmentioning

confidence: 99%

Evolutionary, comparative, and functional analyses of STATs and regulation of the JAK-STAT pathway in lumpfish upon bacterial and poly(I:C) exposure

Rao,

Nelson,

Lunde

et al. 2023

Front. Cell. Infect. Microbiol.

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BackgroundThe Janus kinase/signal transducers and activators of transcription (JAK-STAT) system regulates several biological processes by affecting transcription of genes as a response to cytokines and growth factors. In the present study, we have characterized the STAT genes in lumpfish (Cyclopterus lumpus L.), belonging to the order Perciformes, and investigated regulation of the JAK-STAT signaling pathway upon exposure to bacteria (Vibrio anguillarum) and poly(I:C), the latter mimicking antiviral responses.MethodsCharacterization and evolutionary analyses of the STATs were performed by phylogeny, protein domain, homology similarity and synteny analyses. Antibacterial and antiviral responses were investigated by performing KEGG pathway analysis.ResultsWe observed that lumpfish have stat1a, 2, 3, 4, 5a, 5b, and 6. Transcriptome-wide analyses showed that most components of the JAK-STAT pathway were present in lumpfish. il-6, il-10, il-21, iκBα and stat3 were upregulated 6 hours post exposure (hpe) against bacteria while type I interferons (IFNs), irf1, irf3, irf10, stat1 and 2 were upregulated 24 hpe against poly(I:C).ConclusionsOur findings shed light on the diversity and evolution of the STATs and the data show that the STAT genes are highly conserved among fish, including lumpfish. The transcriptome-wide analyses lay the groundwork for future research into the functional significance of these genes in regulating critical biological processes and make an important basis for development of prophylactic measure such as vaccination, which is highly needed for lumpfish since it is vulnerable for both bacterial and viral diseases.

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Section: Discussionmentioning

confidence: 99%

Evolutionary, comparative, and functional analyses of STATs and regulation of the JAK-STAT pathway in lumpfish upon bacterial and poly(I:C) exposure

Rao,

Nelson,

Lunde

et al. 2023

Front. Cell. Infect. Microbiol.

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“…Type I interferon mediates the innate immune response to control virus infections in invertebrates [71,72]. New members of the signal transducer and activator of transcription (STAT) family have been reported in the chordate amphioxus, which can exert similar biological functions to vertebrate STATs [73]. DCST2 is an important paralog of DCST1.…”

Section: Discussionmentioning

confidence: 99%

Genomic Analysis of Amphioxus Reveals a Wide Range of Fragments Homologous to Viral Sequences

Peng

Xiong

et al. 2023

Viruses

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Amphioxus species are considered living fossils and are important in the evolutionary study of chordates and vertebrates. To explore viral homologous sequences, a high-quality annotated genome of the Beihai amphioxus (Branchiostoma belcheri beihai) was examined using virus sequence queries. In this study, 347 homologous fragments (HFs) of viruses were identified in the genome of B. belcheri beihai, of which most were observed on 21 genome assembly scaffolds. HFs were preferentially located within protein-coding genes, particularly in their CDS regions and promoters. A range of amphioxus genes with a high frequency of HFs is proposed, including histone-related genes that are homologous to the Histone H4 or Histone H2B domains of viruses. Together, this comprehensive analysis of viral HFs provides insights into the neglected role of viral integration in the evolution of amphioxus.

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“…Polyphenols, as earlier stated, may alter the impact of proteins substances that may be employed to enhance cellular survival 57 . STAT proteins (Signal Transducers and Activators of Transcription) support both cell survival and development 58 . Members of this protein family are dephosphorylated by MLF (4'-Methoxy licoflavanone) and AIF (Alpinumi soflavone) which decreases cancer cell survival.…”

Section: Flavonoidsmentioning

confidence: 99%

A Comprehensive Review on Medicinal Plants against Lung Cancer

Pandiyan

Yadav

et al. 2022

Orient. J. Chem

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Lung cancer is a disease with a high probability of occurrence as well as a high mortality rate. Despite the fact that numerous therapies are available, a huge number of patients die each year as a result of cancer. The rising research direction in health care pharmacy paves the way for the development of an effective and side effect-free anticancer medicine. Chemical entities found in plants are extremely useful in cancer studies. Most notary bioactive phytochemicals are preferred because they act differently only on cancer cells exclusively and not normal cells. Carcinogenesis is a multi-step process that involves numerous signaling events. Phytochemicals have a pleiotropic activity which can target these events in a variety of ways, making them an excellent choice for anticancer medication therapy. Efforts are underway to create lead candidates derived from phytochemicals that can reduce the progression of cancer without inducing any side effects. The purpose of this review is to provide information on medicinal plants that have anticancer effect against lung cancer.

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Functional characterization of STATa/b genes encoding transcription factors from Branchiostoma belcheri

Cited by 6 publications

References 47 publications

Evolutionary, comparative, and functional analyses of STATs and regulation of the JAK-STAT pathway in lumpfish upon bacterial and poly(I:C) exposure

Evolutionary, comparative, and functional analyses of STATs and regulation of the JAK-STAT pathway in lumpfish upon bacterial and poly(I:C) exposure

Genomic Analysis of Amphioxus Reveals a Wide Range of Fragments Homologous to Viral Sequences

A Comprehensive Review on Medicinal Plants against Lung Cancer

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