Functional Characterization of X Antigen Genes (XAGEs)

Abstract

Cancer‐testis antigens (CTAs) are a group of genes that are normally expressed in the testis but aberrantly expressed in many different types of cancers. X‐linked antigens (XAGEs) are CTAs that are located on the X chromosome and that remain understudied and their role in cancer remains unclear. The specific expression of XAGEs in cancer cells make them a potential target for cancer therapy. The goal of this research project is to elucidate the biochemical function of XAGE genes and their protein products in normal and diseased states. We will first generate an atlas of cancer cell lines that display XAGE expression. Then we will perform gain and loss of function studies to determine what pathways are perturbed in the presence and absence of XAGEs. We will also determine binding partners of these proteins by IP‐Mass Spectrometry. In summary, our studies will shed light on the biochemical functions of the enigmatic XAGE proteins. Support or Funding Information HRD1764201