Functional chicken-liver hydrolysates ameliorate insulin resistance and cognitive decline in streptozotocin-induced diabetic mice

Yeh, Wei-Yu; Lin, Yi-Ling; Yang, Wen; Chou, Chung‐Hsi; Wu, Yi-Hsieng Samuel; Chen, Yi‐Chen

doi:10.1016/j.psj.2022.101887

Cited by 7 publications

(3 citation statements)

References 34 publications

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“…It was reported that the recommended dietary protein and calorie intake for patients with alcoholic hepatitis are 1.2–1.5 g and 30–40 kcal/day, respectively 22 . Our research team successfully developed a chicken‐liver hydrolysate (CLH) with antioxidant effect, 4 lipid‐lowering effect, 23,24 and amelioration of cognitive dysfunction induced by diabetes 25 . Those benefits are attributed to the free amino‐acid profile and imidazole‐ring dipeptides, that is, anserine (β‐alanyl‐ N ‐histidine), which demonstrate several biological activities, such as antioxidant antioxidative activities, pH buffering, complexing of dangerous carbonyl compounds, anti‐glycation activities on proteins etc 26 .…”

Section: Introductionmentioning

confidence: 99%

“…22 Our research team successfully developed a chicken-liver hydrolysate (CLH) with antioxidant effect, 4 lipid-lowering effect, 23,24 and amelioration of cognitive dysfunction induced by diabetes. 25 Those benefits are attributed to the free amino-acid profile and imidazole-ring dipeptides, that is, anserine (β-alanyl-N-histidine), which demonstrate several biological activities, such as antioxidant antioxidative activities, pH buffering, complexing of dangerous carbonyl compounds, anti-glycation activities on proteins etc. 26 However, recently a hepatoprotection of a CLH-based supplement, GBHP01™ against liver fibrogenesis induced by thioacetamide has been reported as well.…”

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confidence: 99%

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A functional chicken‐liver hydrolysate‐based supplement ameliorates alcohol liver disease via regulation of antioxidation, anti‐inflammation, and antiapoptosis

Wu,

Lin,

Kao

et al. 2023

Environmental Toxicology

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Tons of broiler livers are produced yearly in Taiwan but always considered waste. Our team has successfully patented and characterized a chicken‐liver hydrolysate (CLH) with several biofunctions. Chronic alcohol consumption causes hepatosteatosis or even hepatitis, cirrhosis, and cancers. This study was to investigate the hepatoprotection of CLH‐based supplement (GBHP01™) against chronic alcohol consumption. Results showed that GBHP01™ could reduce (p < .05) enlarged liver size, lipid accumulation/steatosis scores, and higher serum AST, ALT, γ‐GT, triglyceride, and cholesterol levels induced by an alcoholic liquid diet. GBHP01™ reduced liver inflammation and apoptosis in alcoholic liquid‐diet‐fed mice via decreasing TBARS, interleukin‐6, interleukin‐1β, and tumor necrosis factor‐α levels, increasing reduced GSH/TEAC levels and activities of SOD, CAT and GPx, as well as downregulating CYP2E1, BAX/BCL2, Cleaved CASPASE‐9/Total CASPASE‐9 and Active CASPASE‐3/Pro‐CASPASE‐3 (p < .05). Furthermore, GBHP01™ elevated hepatic alcohol metabolism (ADH and ALDH activities) (p < .05). In conclusion, this study prove the hepatoprotection of GBHP01™ against alcohol consumption.

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Section: Introductionmentioning

confidence: 99%

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confidence: 99%

A functional chicken‐liver hydrolysate‐based supplement ameliorates alcohol liver disease via regulation of antioxidation, anti‐inflammation, and antiapoptosis

Wu,

Lin,

Kao

et al. 2023

Environmental Toxicology

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“…Chicken is an important source of peptides with various beneficial bioactivities, including antioxidation, anti-pancreatic lipase activity, anti-hypertension, alcohol dehydrogenase stabilization, immune boosting, insulin resistance amelioration, and learning enhancement [ 4 , 16 , 17 , 18 , 19 , 20 , 21 ]. Moreover, the bioactive agents derived from poultry industrial products or co-products will provide advantages such as unlimited and manageable supplies, a bio-circular and green economy, and industry sustainability.…”

Section: Introductionmentioning

confidence: 99%

Anserine/Carnosine-Rich Extract from Thai Native Chicken Suppresses Melanogenesis via Activation of ERK Signaling Pathway

et al. 2022

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Skin hyperpigmentation is an aesthetic problem that leads to psychosocial issues. Thus, skin whitening agents from agro- and poultry-industrial co-products are considered high economic value ingredients of interest for sustainable application. Therefore, this study aimed to determine the cosmeceutical potential of anserine/carnosine-rich chicken extract (ACCE) from the Thai native chicken Pradu Hang Dam Mor Kor 55 (PD) meat. The chemical composition was identified and quantified using the HPLC-UV method. Then, the antioxidation potential of the extract was compared to that of L-anserine and L-carnosine, using 1,1-diphenyl-2-picrylhydrazyl assay and shikonin-induced production of reactive oxygen species in CCD-986Sk cell models, and the anti-melanogenesis effect in the MNT-1 melanoma cell line model was investigated. Furthermore, related mechanisms were identified using colorimetric tyrosinase assay and the Western blot technique. The ACCE was composed of L-anserine and L-carnosine as two major constituents. In a dose-dependent manner, ACCE, L-anserine, and L-carnosine manifested significant antioxidation potential and significant reduction of melanin production. Activation of the extracellular signal-regulated kinase (ERK) signaling pathway and inhibition of tyrosinase activity of ACCE were demonstrated as the mechanisms of the anti-melanogenesis effect. In conclusion, ACCE has been revealed as a potential cosmeceutical agent due to its antioxidation and anti-melanogenic activity in association with L-anserine and L-carnosine composition and biomolecular regulating ability. Therefore, further studies and development should be considered to support the utilization of anserine/carnosine-rich chicken extract in the cosmetic industry for economic value creation and sustainability.

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The effect on product structure and volatile compounds of chicken liver by fermentation

Zou,

Wang,

Niu

et al. 2023

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Functional chicken-liver hydrolysates ameliorate insulin resistance and cognitive decline in streptozotocin-induced diabetic mice

Cited by 7 publications

References 34 publications

A functional chicken‐liver hydrolysate‐based supplement ameliorates alcohol liver disease via regulation of antioxidation, anti‐inflammation, and antiapoptosis

A functional chicken‐liver hydrolysate‐based supplement ameliorates alcohol liver disease via regulation of antioxidation, anti‐inflammation, and antiapoptosis

Anserine/Carnosine-Rich Extract from Thai Native Chicken Suppresses Melanogenesis via Activation of ERK Signaling Pathway

The effect on product structure and volatile compounds of chicken liver by fermentation

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