Abstract:The purpose of this study was to investigate the effects of two types of Transcutaneous Electrical Nerve Stimulation (TENS) on walking distance and measures of pain in patients with Peripheral Arterial Disease (PAD) and Intermittent Claudication (IC). In a phase 2a study, forty participants with PAD and IC completed a graded treadmill test on two separate testing occasions. Active TENS was applied to the lower limb on the first occasion and placebo TENS on the second. Participants were divided into two experimental groups. One group received High-Frequency TENS (HF-TENS), the other increased walking distance on a treadmill but not with any reduction in pain. TENS may be a useful adjunctive intervention to help increase walking performance in patients with IC.