Brain activation through computer training of attention and executive function could stimulate brain plasticity in patients with Mild Cognitive Impairment (MCI). Aim: The study aimed to investigate the effectiveness of a computer based training on visual spatial abilities, visual attention, executive function and visual memory, in MCI patients. Method: The participants were 59 MCI patients, age 68.08 (7.25), education 9.17 (3.93), and MMSE 27.73 (1.35), classified in one experimental (N=30) and one control group (N=29). The groups were matched in age (p= 0.60), education (p= 0.06), drugs (0.51) and gender (p= 0.52). The experimental group attended 20 weekly sessions in a period of 6 months, including tasks of visual attention, visual spatial abilities, visual memory, and executive function. The control group did not participate in any type of intervention and was in a waiting list. Neuropsychological assessment was performed at baseline and at the end of the training. Results: At baseline, there were no between groups differences in cognitive abilities. At the end of the training, between groups comparison yielded differences in favor of the experimental group in attention (p≤ 0.00), verbal fluency (p= 0.00), visual memory (p= 0.01), verbal memory (p=0.00) and learning through feedback (p=0.00). Within group analysis of the experimental group's performance has shown improvement in attention (p=0.00) and daily function (p=0.00). Controls have shown an improvement in perseverant responses and cognitive flexibility (p≤0.00) and naming (p=0.02), and deterioration in abilities of attention (p≤0.00). Conclusion: Computer cognitive training helped the experimental group to improve attention abilities and the improvement was generalized in verbal memory and in ADL as well.